5YLS
Crystal structure of T2R-TTL-Y50 complex
Summary for 5YLS
Entry DOI | 10.2210/pdb5yls/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, E-3-(3-azanyl-4-methoxy-phenyl)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)prop-2-en-1-one, ... (13 entities in total) |
Functional Keywords | colchicine binding domain, tubulin inhibitor, tublin, millepachine, structural protein |
Biological source | Sus scrofa (Pig) More |
Total number of polymer chains | 6 |
Total formula weight | 265344.82 |
Authors | Yang, J.H.,Chen, L.J. (deposition date: 2017-10-18, release date: 2018-04-11, Last modification date: 2024-03-27) |
Primary citation | Yang, J.H.,Yan, W.,Yu, Y.M.,Wang, Y.X.,Yang, T.,Xue, L.L.,Yuan, X.,Long, C.F.,Liu, Z.W.,Chen, X.X.,Hu, M.S.,Zheng, L.,Qiu, Q.,Pei, H.Y.,Li, D.,Wang, F.,Bai, P.,Wen, J.L.,Ye, H.Y.,Chen, L.J. The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 293:9461-9472, 2018 Cited by PubMed: 29691282DOI: 10.1074/jbc.RA117.001658 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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