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6Y4N

Structure of Tubulin Tyrosine Ligase in Complex with Tb116

Summary for 6Y4N
Entry DOI10.2210/pdb6y4n/pdb
DescriptorTubulin alpha-1B chain, (2~{R})-1-methylpiperidine-2-carboxylic acid, [(1~{R},3~{R})-1-(4-methanoyl-1,3-thiazol-2-yl)-4-methyl-3-(methylamino)pentyl] ethanoate, ... (18 entities in total)
Functional Keywordsttl, tubulin, ligase, complex
Biological sourceRattus norvegicus (Norway rat)
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Total number of polymer chains6
Total formula weight265537.38
Authors
Gavrilyuk, J.,Nocek, B.,Rigol, S.,Nicolaou, K.C.,Stoll, V. (deposition date: 2020-02-21, release date: 2021-03-31, Last modification date: 2022-11-23)
Primary citationNicolaou, K.C.,Pan, S.,Pulukuri, K.K.,Ye, Q.,Rigol, S.,Erande, R.D.,Vourloumis, D.,Nocek, B.P.,Munneke, S.,Lyssikatos, J.,Valdiosera, A.,Gu, C.,Lin, B.,Sarvaiaya, H.,Trinidad, J.,Sandoval, J.,Lee, C.,Hammond, M.,Aujay, M.,Taylor, N.,Pysz, M.,Purcell, J.W.,Gavrilyuk, J.
Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis.
J.Org.Chem., 86:3377-3421, 2021
Cited by
PubMed: 33544599
DOI: 10.1021/acs.joc.0c02755
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.852 Å)
Structure validation

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