6Y4N
Structure of Tubulin Tyrosine Ligase in Complex with Tb116
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Tubulin alpha-1B chain | polymer | 451 | 50204.4 | 2 | UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (Pig) | Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain |
| 2 | B, D (B, D) | Tubulin beta chain | polymer | 445 | 49907.8 | 2 | UniProt (P02554) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (Pig) | Beta-tubulin |
| 3 | E (E) | Stathmin-4 | polymer | 143 | 16844.2 | 1 | UniProt (P63043) Pfam (PF00836) | Rattus norvegicus (Norway rat) | Stathmin-like protein B3,RB3 |
| 4 | F (F) | Tubulin-Tyrosine Ligase | polymer | 384 | 44378.5 | 1 | UniProt (E1BQ43) | Gallus gallus (Chicken) | |
| 5 | G, P, V (A, C, D) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 3 | Chemie (GTP) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) | |||
| 6 | H, K, Q, W, Z (A, B, C, D, F) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) PubChem (888) | |||
| 7 | I, R (A, C) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) PubChem (271) | |||
| 8 | J (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) PubChem (136073927) | |||
| 9 | L (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) PubChem (4478249) | |||
| 10 | M (B) | (2~{R})-1-methylpiperidine-2-carboxylic acid | non-polymer | 143.2 | 1 | Chemie (O9B) PubChem (415939) PubChem (6993266) PubChem (11286529) | |||
| 11 | N (B) | [(1~{R},3~{R})-1-(4-methanoyl-1,3-thiazol-2-yl)-4-methyl-3-(methylamino)pentyl] ethanoate | non-polymer | 284.4 | 1 | Chemie (O9K) PubChem (146691205) | |||
| 12 | O (B) | methyl (2~{S},4~{S})-2,4-bis(azanyl)-5-phenyl-pentanoate | non-polymer | 222.3 | 1 | Chemie (O9N) PubChem (155818882) | |||
| 13 | S (C) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 14 | T (C) | VALINE | non-polymer | 117.1 | 1 | Chemie (VAL) PubChem (1182) PubChem (6287) PubChem (71563) | |||
| 15 | U (C) | benzyl hydrogen carbonate | non-polymer | 152.1 | 1 | Chemie (P6S) PubChem (2285) | |||
| 16 | X (D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) PubChem (8117) | |||
| 17 | Y (F) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) PubChem (46936826) PubChem (134943439) PubChem (157749839) PubChem (91532) PubChem (91885473) PubChem (157749842) PubChem (4799) | |||
| 18 | AA, BA, CA, DA, EA... (A, B, C, D, E...) | water | water | 18.0 | 601 | Chemie (HOH) |
Sequence modifications
E: 49 - 189 (UniProt: P63043)
F: 1 - 378 (UniProt: E1BQ43)
| PDB | External Database | Details |
|---|---|---|
| Met 47 | - | expression tag |
| Ala 48 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His 379 | - | expression tag |
| His 380 | - | expression tag |
| His 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 261447.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 4090.3 | |
| All* | Total formula weight | 265537.4 |
