7LZ8

Tubulin-RB3_SLD-TTL in complex with compound 5t

Summary for 7LZ8

Entry DOI	10.2210/pdb7lz8/pdb
Descriptor	Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[2-(ethylamino)pyrido[3,2-d]pyrimidin-4-yl]-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, ... (13 entities in total)
Functional Keywords	microtubule inhibitor, colchicine, cell cycle, cancer, cell cycle-inhibitor complex, cell cycle/inhibitor
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	6
Total formula weight	265242.59
Authors	White, S.W.,Yun, M. (deposition date: 2021-03-09, release date: 2021-09-22, Last modification date: 2023-10-18)
Primary citation	Banerjee, S.,Mahmud, F.,Deng, S.,Ma, L.,Yun, M.K.,Fakayode, S.O.,Arnst, K.E.,Yang, L.,Chen, H.,Wu, Z.,Lukka, P.B.,Parmar, K.,Meibohm, B.,White, S.W.,Wang, Y.,Li, W.,Miller, D.D. X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. J.Med.Chem., 64:13072-13095, 2021 Cited by PubMed: 34406768 DOI: 10.1021/acs.jmedchem.1c01202 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.92 Å)

Structure validation