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PDB: 354 件
1JK8
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Crystal structure of a human insulin peptide-HLA-DQ8 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ8, insulin B peptide
著者Lee, K.H, Wucherpfennig, K.W, Wiley, D.C.
登録日2001-07-11
公開日2001-08-22
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.
Nat.Immunol., 2, 2001
1QJ0
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BU of 1qj0 by Molmil
HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR
分子名称: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ...
著者Tang, L, Whittingham, J.L, Verma, C.S, Caves, L.S.D, Dodson, G.G.
登録日1999-06-18
公開日1999-06-22
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis.
Biochemistry, 38, 1999
4GBK
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BU of 4gbk by Molmil
Crystal structure of aspart insulin at pH 8.5
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Lima, L.M.T.R, Favero-Retto, M.P, Palmieri, L.C.
登録日2012-07-27
公開日2013-06-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A T3R3 hexamer of the human insulin variant B28Asp.
Biophys.Chem., 173, 2013
2WRW
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Semi-synthetic highly active analogue of human insulin D-ProB26-DTI- NH2
分子名称: INSULIN A CHAIN, INSULIN B CHAIN
著者Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G.
登録日2009-09-02
公開日2010-02-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
5URU
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BU of 5uru by Molmil
Insulin with proline analog DhP at position B28 in the R6 state
分子名称: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ...
著者Lieblich, S.A, Fang, K.Y, Tirrell, D.A.
登録日2017-02-13
公開日2018-02-21
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Insulin with proline analog DhP at position B28 in the R6 state
To Be Published
6Z7W
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BU of 6z7w by Molmil
Human insulin in complex with the analytical antibody HUI-018 Fab
分子名称: HUI-018 Fab Heavy Chain, Insulin, MAb 6H10 light chain
著者Johansson, E.
登録日2020-06-02
公開日2020-12-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties.
Protein Sci., 30, 2021
7NMG
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Human MHC Class I, A24 Allele presenting LWM, Complex with 4C6 TCR
分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Diabetes epitope LWMRLLPLL, ...
著者Rizkallah, P.J, Sewell, A.K, Cole, D.K, Wall, A.
登録日2021-02-23
公開日2022-09-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Human MHC Class I, A24 Allele presenting LWM, Complex with 4C6 TCR
To Be Published
4GBL
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BU of 4gbl by Molmil
Crystal structure of aspart insulin at pH 8.5
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Lima, L.M.T.R, Favero-Retto, M.P, Palmieri, L.C.
登録日2012-07-27
公開日2013-06-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A T3R3 hexamer of the human insulin variant B28Asp.
Biophys.Chem., 173, 2013
8Z4B
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BU of 8z4b by Molmil
Crystal structure of LysB22-AspB28 insulin analog at ambient structure
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Ayan, E, Demirci, H.
登録日2024-04-17
公開日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of LysB22-AspB28 insulin analog at ambient structure
To Be Published
4Y19
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immune complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FS18_alpha, FS18_beta, ...
著者Beringer, D.X, Petersen, J, Reid, H.H, Rossjohn, J.
登録日2015-02-07
公開日2015-09-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex.
Nat.Immunol., 16, 2015
1JCA
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BU of 1jca by Molmil
Non-standard Design of Unstable Insulin Analogues with Enhanced Activity
分子名称: ZINC ION, insulin a, insulin b
著者Weiss, M.A, Wan, Z, Zhao, M, Chu, Y.-C, Nakagawa, S.H, Burke, G.T, Jia, W, Hellmich, R, Katsoyannis, P.G.
登録日2001-06-08
公開日2001-06-20
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
3JSD
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BU of 3jsd by Molmil
Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G.
登録日2009-09-10
公開日2010-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
1B9E
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BU of 1b9e by Molmil
HUMAN INSULIN MUTANT SERB9GLU
分子名称: PROTEIN (INSULIN)
著者Wang, D.C, Zeng, Z.H, Yao, Z.P, Li, H.M.
登録日1998-11-12
公開日1999-11-17
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of an insulin dimer in an orthorhombic crystal: the structure analysis of a human insulin mutant (B9 Ser-->Glu).
Acta Crystallogr.,Sect.D, 55, 1999
4GBI
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BU of 4gbi by Molmil
Crystal structure of aspart insulin at pH 6.5
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Lima, L.M.T.R, Favero-Retto, M.P, Palmieri, L.C.
登録日2012-07-27
公開日2013-06-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.502 Å)
主引用文献A T3R3 hexamer of the human insulin variant B28Asp.
Biophys.Chem., 173, 2013
2WS7
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BU of 2ws7 by Molmil
Semi-synthetic analogue of human insulin ProB26-DTI
分子名称: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ...
著者Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G.
登録日2009-09-03
公開日2010-02-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
7KD6
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BU of 7kd6 by Molmil
Insulin Receptor L1-CR plus alphaCT fragment in co-complex with Fv 83-7 and single-chain insulin SCI-b
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Lawrence, M.C, Menting, J.G.
登録日2020-10-08
公開日2021-10-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Single-chain insulin analogs threaded by the insulin receptor alpha CT domain.
Biophys.J., 2022
2WBY
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BU of 2wby by Molmil
Crystal structure of human insulin-degrading enzyme in complex with insulin
分子名称: INSULIN A CHAIN, INSULIN B CHAIN, INSULIN-DEGRADING ENZYME, ...
著者Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J.
登録日2009-03-06
公開日2009-03-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
3UTT
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BU of 3utt by Molmil
1E6-A*0201-ALWGPDPAAA Complex, Triclinic
分子名称: 1E6 TCR Alpha Chain, 1E6 TCR Beta Chain, Beta-2-microglobulin, ...
著者Rizkallah, P.J, Cole, D.K, Sewell, A.K, Bulek, A.M, Rossjohn, J, Gras, S.
登録日2011-11-26
公開日2012-01-25
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nat.Immunol., 13, 2012
3UTS
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BU of 3uts by Molmil
1E6-A*0201-ALWGPDPAAA Complex, Monoclinic
分子名称: 1E6 TCR Alpha Chain, 1E6 TCR Beta Chain, Beta-2-microglobulin, ...
著者Rizkallah, P.J, Cole, D.K, Sewell, A.K, Bulek, A.M.
登録日2011-11-26
公開日2012-01-25
最終更新日2012-03-07
実験手法X-RAY DIFFRACTION (2.712 Å)
主引用文献Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nat.Immunol., 13, 2012
4UNH
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BU of 4unh by Molmil
Human insulin B26Gly mutant crystal structure
分子名称: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION
著者Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M.
登録日2014-05-28
公開日2014-10-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex
Acta Crystallogr.,Sect.D, 70, 2014
2WC0
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crystal structure of human insulin degrading enzyme in complex with iodinated insulin
分子名称: 1,4-DIETHYLENE DIOXIDE, INSULIN A CHAIN, INSULIN B CHAIN, ...
著者Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J.
登録日2009-03-06
公開日2009-03-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
5WDM
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An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein
分子名称: Single-chain insulin analog
著者Yee, V.C, Aldabbagh, K, Peng, Y.
登録日2017-07-05
公開日2017-11-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.803 Å)
主引用文献An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.
J. Biol. Chem., 293, 2018
6VEP
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Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Lawrence, M.C, Menting, J.G.T.
登録日2020-01-02
公開日2020-06-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Nat.Struct.Mol.Biol., 27, 2020
8HSF
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BU of 8hsf by Molmil
Insulin triple mutant INS-RQD
分子名称: Insulin A chain, Insulin B chain
著者Kundapura, S.V, Rao, S.S, Kulal, A, Ramagopal, U.A.
登録日2022-12-19
公開日2023-12-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Insulin triple mutant INS-RQD
To Be Published
7RZI
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Insulin Degrading Enzyme pC/pC
分子名称: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain
著者Mancl, J.M, Liang, W.G, Tang, W.J.
登録日2021-08-27
公開日2022-08-31
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published

222624

件を2024-07-17に公開中

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