1JK8

Crystal structure of a human insulin peptide-HLA-DQ8 complex

Summary for 1JK8

• Entry DOI: 10.2210/pdb1jk8/pdb
• Descriptor: MHC class II HLA-DQ8, insulin B peptide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: hla-dq8, insulin b peptide, type 1 diabetes, autoimmunity, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 44724.12

Authors

Lee, K.H.,Wucherpfennig, K.W.,Wiley, D.C. (deposition date: 2001-07-11, release date: 2001-08-22, Last modification date: 2024-10-16)

Primary citation

Lee, K.H.,Wucherpfennig, K.W.,Wiley, D.C.
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.
Nat.Immunol., 2:501-507, 2001

PubMed Abstract: The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the major risk factors for increased susceptibility to type 1 diabetes. Using X-ray crystallography, we have determined the three-dimensional structure of DQ8 complexed with an immunodominant peptide from insulin. The similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests that diabetes is caused by the same antigen-presentation event(s) in humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes.

PubMed: 11376336
DOI: 10.1038/88694

Experimental method

X-RAY DIFFRACTION (2.4 Å)