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PDB: 354 件
5HPR
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BU of 5hpr by Molmil
Insulin with proline analog HyP at position B28 in the T2 state
分子名称: GLYCEROL, Insulin A-Chain, Insulin B-Chain, ...
著者Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A.
登録日2016-01-21
公開日2017-01-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
5UDP
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BU of 5udp by Molmil
High resolution x-ray crystal structure of synthetic insulin lispro
分子名称: CHLORIDE ION, Insulin Lispro A chain, Insulin Lispro B chain, ...
著者Mandal, K, Dhayalan, B, Kent, S.B.H.
登録日2016-12-28
公開日2017-01-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.348 Å)
主引用文献Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin.
Chemistry, 23, 2017
3FQ9
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BU of 3fq9 by Molmil
Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications
分子名称: Insulin, ZINC ION
著者Zhao, M, Wan, Z.L, Whittaker, L, Xu, B, Phillips, N, Katsoyannis, P, Whittaker, J, Weiss, M.A.
登録日2009-01-07
公開日2009-08-04
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
5ENA
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BU of 5ena by Molmil
Xray crystal structure of isotope-labeled human insulin
分子名称: Insulin chain A, Insulin chain B
著者Mandal, K, Dhayalan, B, Avital-Shmilovici, M, Tokmakoff, A, Kent, S.B.H.
登録日2015-11-09
公開日2016-01-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin.
Chembiochem, 17, 2016
6S34
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BU of 6s34 by Molmil
Zinc free, dimeric human insulin determined to 1.35 Angstrom resolution
分子名称: 1,2-ETHANEDIOL, Insulin A chain, Insulin B chain
著者Johansson, E.
登録日2019-06-24
公開日2019-07-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Zinc free, dimeric human insulin determined to 1.35 Angstrom resolution
Not Published
3EXX
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BU of 3exx by Molmil
Structure of the T6 human insulin derivative with nickel at 1.35 A resolution
分子名称: Insulin A chain, Insulin B chain, NICKEL (II) ION, ...
著者Prugovecki, B, Matkovic-Calogovic, D.
登録日2008-10-17
公開日2009-05-19
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structure of the T6 Human Nickel Insulin Derivative at 1.35 A Resolution.
CROATICA CHEMICA ACTA, 82, 2009
6TC2
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BU of 6tc2 by Molmil
Monoclinic human insulin in complex with p-coumaric acid
分子名称: 4'-HYDROXYCINNAMIC ACID, Insulin, PHOSPHATE ION, ...
著者Triandafillidis, D.-P, Parthenios, N, Spiliopoulou, M, Valmas, A, Kosinas, C, Gozzo, F, Reinle-Schmitt, M, Beckers, D, Degen, T, Pop, M, Fitch, A, Wollenhaupt, J, Weiss, M.S, Karavassili, F, Margiolaki, I.
登録日2019-11-04
公開日2020-11-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Insulin polymorphism induced by two polyphenols: new crystal forms and advances in macromolecular powder diffraction.
Acta Crystallogr D Struct Biol, 76, 2020
2OMH
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BU of 2omh by Molmil
Structure of human insulin cocrystallized with ARG-12 peptide in presence of urea
分子名称: CHLORIDE ION, FORMAMIDE, Insulin A chain, ...
著者Norrman, M, Schluckebier, G.
登録日2007-01-22
公開日2007-03-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Structural characterization of insulin NPH formulations.
EUR.J.PHARM.SCI., 30, 2007
7NHU
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BU of 7nhu by Molmil
Crystal structure of desB30 insulin produced by cell free protein synthesis
分子名称: Insulin
著者Johansson, E.
登録日2021-02-11
公開日2021-06-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Cell free protein synthesis versus yeast expression - A comparison using insulin as a model protein.
Protein Expr.Purif., 186, 2021
7Z5L
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BU of 7z5l by Molmil
Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and dimethyl sulfoxide (DMSO)
分子名称: GLYCEROL, Insulin A chain, Insulin B chain, ...
著者van den Elsen, J.M.H, Wahid, A.A, Crennell, C.
登録日2022-03-09
公開日2023-03-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling
To Be Published
3W80
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BU of 3w80 by Molmil
Crystal structure of dodecamer human insulin with double C-axis length of the hexamer 2 Zn insulin cell
分子名称: Insulin, ZINC ION
著者Murayoshi, M, Sasaki, K, Sakabe, N, Sakabe, K.
登録日2013-03-11
公開日2013-07-03
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structure of dodecamer insulin with double C-axis length of the hexamer 2 Zn insulin celll
To be Published
8IPZ
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BU of 8ipz by Molmil
Crystal structure of insulin detemir
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者DeMirci, H, Ayan, E.
登録日2023-03-15
公開日2023-12-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structure of insulin detemir
To Be Published
4NIB
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BU of 4nib by Molmil
Crystal structure of human insulin mutant B20 D-ala, B23 D-ala
分子名称: Insulin A chain, Insulin B chain
著者Menting, J.G, Lawrence, M.C.
登録日2013-11-05
公開日2014-08-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4CY7
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BU of 4cy7 by Molmil
Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form II
分子名称: ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN, ...
著者Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L.
登録日2014-04-10
公開日2014-05-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin.
Biochemistry, 53, 2014
1BEN
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BU of 1ben by Molmil
INSULIN COMPLEXED WITH 4-HYDROXYBENZAMIDE
分子名称: 4-HYDROXYBENZAMIDE, CHLORIDE ION, HUMAN INSULIN, ...
著者Smith, G.D, Ciszak, E, Pangborn, W.
登録日1996-02-15
公開日1996-07-11
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献A novel complex of a phenolic derivative with insulin: structural features related to the T-->R transition.
Protein Sci., 5, 1996
6VET
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BU of 6vet by Molmil
Human insulin analog: [GluB10,HisA8,ArgA9,TyrB20]-DOI
分子名称: Insulin A chain, Insulin B chain
著者Menting, J.G, Chou, D.H.-C, Lawrence, M.C, Xiong, X.
登録日2020-01-02
公開日2020-06-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Nat.Struct.Mol.Biol., 27, 2020
4EY1
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BU of 4ey1 by Molmil
Human Insulin
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R.
登録日2012-05-01
公開日2013-05-01
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.471 Å)
主引用文献Structural meta-analysis of regular human insulin in pharmaceutical formulations.
Eur J Pharm Biopharm, 85, 2013
4EY9
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BU of 4ey9 by Molmil
Human Insulin
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R.
登録日2012-05-01
公開日2013-05-01
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.471 Å)
主引用文献Structural meta-analysis of regular human insulin in pharmaceutical formulations.
Eur J Pharm Biopharm, 85, 2013
4EYD
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BU of 4eyd by Molmil
Human Insulin
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R.
登録日2012-05-01
公開日2013-05-01
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.471 Å)
主引用文献Structural meta-analysis of regular human insulin in pharmaceutical formulations.
Eur J Pharm Biopharm, 85, 2013
4XC4
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BU of 4xc4 by Molmil
Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide
分子名称: CHLORIDE ION, Insulin, SODIUM ION, ...
著者Bracey, A.W, Magis, A.T, Buschard, K, Osterbye, T, Bailey, K.M, Ostrov, D.A.
登録日2014-12-17
公開日2015-02-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.499 Å)
主引用文献Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide
To Be Published
4CXL
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BU of 4cxl by Molmil
Human insulin analogue (D-ProB8)-insulin
分子名称: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN
著者Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L.
登録日2014-04-07
公開日2014-05-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin.
Biochemistry, 53, 2014
6S4J
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BU of 6s4j by Molmil
Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB27, desB30 human insulin
分子名称: IMIDAZOLE, Insulin, KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]
著者Johansson, E.
登録日2019-06-28
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Molecular engineering of safe and efficacious oral basal insulin.
Nat Commun, 11, 2020
4P65
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BU of 4p65 by Molmil
Crystal structure of an cyclohexylalanine substituted insulin analog.
分子名称: CHLORIDE ION, Insulin, PHENOL, ...
著者Pandyarajan, V, Wan, Z, Weiss, M.A.
登録日2014-03-21
公開日2014-10-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.
J.Biol.Chem., 289, 2014
5EN9
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BU of 5en9 by Molmil
High resolution x-ray crystal structure of isotope-labeled ester-insulin
分子名称: Insulin chain A, Insulin chain B
著者Mandal, K, Dhayalan, B, Avital-Shmilovici, M, Tokmakoff, A, Kent, S.B.H.
登録日2015-11-09
公開日2016-01-13
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin.
Chembiochem, 17, 2016
2C8R
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BU of 2c8r by Molmil
insuline(60sec) and UV laser excited fluorescence
分子名称: INSULIN A CHAIN, INSULIN B CHAIN
著者Vernede, X, Lavault, B, Ohana, J, Nurizzo, D, Joly, J, Jacquamet, L, Felisaz, F, Cipriani, F, Bourgeois, D.
登録日2005-12-06
公開日2006-03-08
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Uv Laser-Excited Fluorescence as a Tool for the Visualization of Protein Crystals Mounted in Loops.
Acta Crystallogr.,Sect.D, 62, 2006

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