6TRJ
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![BU of 6trj by Molmil](/molmil-images/mine/6trj) | LEDGF/p75 IBD dimer | 分子名称: | PC4 and SFRS1-interacting protein | 著者 | Kugler, M, Brynda, J. | 登録日 | 2019-12-19 | 公開日 | 2020-09-09 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Fine-tuning of the LEDGF/p75 interaction network by dimerization Structure
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5N88
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![BU of 5n88 by Molmil](/molmil-images/mine/5n88) | Crystal structure of antibody bound to viral protein | 分子名称: | PC4 and SFRS1-interacting protein, VH59 antibody | 著者 | Bao, L, Hannon, C, Cruz-Migoni, A, Ptchelkine, D, Sun, M.-y, Derveni, M, Bunjobpol, W, Chambers, J.S, Simmons, A, Phillips, S.E.V, Rabbitts, T.H. | 登録日 | 2017-02-23 | 公開日 | 2017-12-20 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein. Sci Rep, 7, 2017
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2B4J
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![BU of 2b4j by Molmil](/molmil-images/mine/2b4j) | Structural basis for the recognition between HIV-1 integrase and LEDGF/p75 | 分子名称: | GLYCEROL, Integrase (IN), PC4 and SFRS1 interacting protein, ... | 著者 | Cherepanov, P, Ambrosio, A.L, Rahman, S, Ellenberger, T, Engelman, A. | 登録日 | 2005-09-24 | 公開日 | 2005-10-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75 Proc.Natl.Acad.Sci.Usa, 102, 2005
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5OYM
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![BU of 5oym by Molmil](/molmil-images/mine/5oym) | HIV Integrase Binding Domain of Lens Epithelium-Derived Growth Factor | 分子名称: | PC4 and SFRS1-interacting protein | 著者 | Rabbitts, T.H, Phillips, S.E.V, Cruz-Migoni, A, Carr, S.B, Hannon, C. | 登録日 | 2017-09-11 | 公開日 | 2018-03-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor. Acta Crystallogr F Struct Biol Commun, 74, 2018
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4FU6
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![BU of 4fu6 by Molmil](/molmil-images/mine/4fu6) | Crystal structure of the PSIP1 PWWP domain | 分子名称: | GLYCEROL, PC4 and SFRS1-interacting protein, SULFATE ION, ... | 著者 | Qin, S, Tempel, W, Xu, C, Wu, H, Dong, A, Cerovina, T, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2012-06-28 | 公開日 | 2012-08-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure and function of the nucleosome-binding PWWP domain. Trends Biochem.Sci., 39, 2014
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3HPH
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![BU of 3hph by Molmil](/molmil-images/mine/3hph) | Closed tetramer of Visna virus integrase (residues 1-219) in complex with LEDGF IBD | 分子名称: | GLYCEROL, Integrase, PC4 and SFRS1-interacting protein, ... | 著者 | Hare, S, Wang, J, Cherepanov, P. | 登録日 | 2009-06-04 | 公開日 | 2009-07-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Structural basis for functional tetramerization of lentiviral integrase Plos Pathog., 5, 2009
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8PEO
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![BU of 8peo by Molmil](/molmil-images/mine/8peo) | H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex | 分子名称: | (2R)-2-amino-3-(2-dimethylaminoethylsulfanyl)propanoic acid, Histone H2A, Histone H2B 1.1, ... | 著者 | Koutna, E, Kouba, T, Veverka, V. | 登録日 | 2023-06-14 | 公開日 | 2023-08-16 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | 主引用文献 | Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
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7OUF
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![BU of 7ouf by Molmil](/molmil-images/mine/7ouf) | Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor XZ450 | 分子名称: | 4-azanyl-~{N}-[[2,4-bis(fluoranyl)phenyl]methyl]-6-[3-(dimethylamino)-3-oxidanylidene-propyl]-1-oxidanyl-2-oxidanylidene-1,8-naphthyridine-3-carboxamide, DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3'), ... | 著者 | Barski, M.S, Ballandras-Colas, A, Cronin, N.B, Pye, V.E, Cherepanov, P, Maertens, G.N. | 登録日 | 2021-06-11 | 公開日 | 2021-08-18 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures. Nat Commun, 12, 2021
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3U88
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![BU of 3u88 by Molmil](/molmil-images/mine/3u88) | Crystal structure of human menin in complex with MLL1 and LEDGF | 分子名称: | (4beta,8alpha,9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol, CHOLIC ACID, GLYOXYLIC ACID, ... | 著者 | Huang, J, Wan, B, Lei, M. | 登録日 | 2011-10-16 | 公開日 | 2012-02-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature, 482, 2012
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8PC5
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![BU of 8pc5 by Molmil](/molmil-images/mine/8pc5) | H3K36me3 nucleosome-LEDGF/p75 PWWP domain complex | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3, ... | 著者 | Koutna, E, Kouba, T, Veverka, V. | 登録日 | 2023-06-09 | 公開日 | 2023-08-16 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
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8PC6
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![BU of 8pc6 by Molmil](/molmil-images/mine/8pc6) | H3K36me3 nucleosome-LEDGF/p75 PWWP domain complex - pose 2 | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3, ... | 著者 | Koutna, E, Kouba, T, Veverka, V. | 登録日 | 2023-06-09 | 公開日 | 2023-08-16 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
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7OUG
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![BU of 7oug by Molmil](/molmil-images/mine/7oug) | STLV-1 intasome:B56 in complex with the strand-transfer inhibitor raltegravir | 分子名称: | DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3'), Integrase, ... | 著者 | Barski, M.S, Ballandras-Colas, A, Cronin, N.B, Pye, V.E, Cherepanov, P, Maertens, G.N. | 登録日 | 2021-06-11 | 公開日 | 2021-08-18 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures. Nat Commun, 12, 2021
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6S01
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![BU of 6s01 by Molmil](/molmil-images/mine/6s01) | Structure of LEDGF PWWP domain bound H3K36 methylated nucleosome | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3, ... | 著者 | Wang, H, Farnung, L, Dienemann, C, Cramer, P. | 登録日 | 2019-06-13 | 公開日 | 2019-12-18 | 最終更新日 | 2020-01-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding. Nat.Struct.Mol.Biol., 27, 2020
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3F9K
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![BU of 3f9k by Molmil](/molmil-images/mine/3f9k) | |
3HPG
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![BU of 3hpg by Molmil](/molmil-images/mine/3hpg) | |
8PEP
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![BU of 8pep by Molmil](/molmil-images/mine/8pep) | H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex - pose 2 | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3, ... | 著者 | Koutna, E, Kouba, T, Veverka, V. | 登録日 | 2023-06-14 | 公開日 | 2023-08-16 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
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8CBN
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![BU of 8cbn by Molmil](/molmil-images/mine/8cbn) | structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3, ... | 著者 | Koutna, E, Kouba, T, Novacek, J, Veverka, V. | 登録日 | 2023-01-25 | 公開日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
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7PEL
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![BU of 7pel by Molmil](/molmil-images/mine/7pel) | CryoEM structure of simian T-cell lymphotropic virus intasome in complex with PP2A regulatory subunit B56 gamma | 分子名称: | DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3'), Isoform 3 of PC4 and SFRS1-interacting protein,Isoform Gamma-2 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, ... | 著者 | Barski, M, Pye, V.E, Nans, A, Cherepanov, P, Maertens, G.N. | 登録日 | 2021-08-10 | 公開日 | 2021-08-25 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56gamma. Nat Commun, 11, 2020
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7OUH
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![BU of 7ouh by Molmil](/molmil-images/mine/7ouh) | Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor bictegravir | 分子名称: | Bictegravir, DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3'), ... | 著者 | Barski, M.S, Ballandras-Colas, A, Cronin, N.B, Pye, V.E, Cherepanov, P, Maertens, G.N. | 登録日 | 2021-06-11 | 公開日 | 2021-08-18 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures. Nat Commun, 12, 2021
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7Z1Z
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![BU of 7z1z by Molmil](/molmil-images/mine/7z1z) | MVV strand transfer complex (STC) intasome in complex with LEDGF/p75 at 3.5 A resolution | 分子名称: | DNA (37-MER), DNA (5'-D(*GP*CP*TP*GP*CP*GP*AP*GP*AP*TP*CP*CP*GP*CP*TP*CP*CP*GP*GP*TP*G)-3'), DNA (5'-D(P*TP*TP*GP*AP*TP*TP*AP*GP*GP*GP*TP*G)-3'), ... | 著者 | Pye, V.E, Ballandras-Colas, A, Cherepanov, P. | 登録日 | 2022-02-25 | 公開日 | 2022-05-11 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Multivalent interactions essential for lentiviral integrase function. Nat Commun, 13, 2022
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8CBQ
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![BU of 8cbq by Molmil](/molmil-images/mine/8cbq) | structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3, ... | 著者 | Koutna, E, Kouba, T, Novacek, J, Veverka, V. | 登録日 | 2023-01-25 | 公開日 | 2023-09-06 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
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6EMR
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![BU of 6emr by Molmil](/molmil-images/mine/6emr) | |
6EMP
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![BU of 6emp by Molmil](/molmil-images/mine/6emp) | |
6EMO
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![BU of 6emo by Molmil](/molmil-images/mine/6emo) | |
6EMQ
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![BU of 6emq by Molmil](/molmil-images/mine/6emq) | |