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PDB: 216 件
2Y3J
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Structure of segment AIIGLM from the amyloid-beta peptide (Ab, residues 30-35)
分子名称: AMYLOID BETA A4 PROTEIN
著者Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D.
登録日2010-12-21
公開日2011-11-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Molecular Basis for Amyloid-{Beta} Polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
4OJF
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Humanised 3D6 Fab complexed to amyloid beta 1-8
分子名称: Amyloid beta A4 protein, Humanised 3D6 Fab Heavy Chain, Humanised 3D6 Fab Light Chain
著者Miles, L.A, Crespi, G.A.N, Parker, M.W.
登録日2014-01-21
公開日2015-01-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.998 Å)
主引用文献Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-beta
ACTA CRYSTALLOGR.,SECT.F, 70, 2014
4ONF
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Fab fragment of 3D6 in complex with amyloid beta 1-7
分子名称: 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein
著者Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S.
登録日2014-01-28
公開日2014-06-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab.
Alzheimers Res Ther, 6, 2014
3UMH
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BU of 3umh by Molmil
X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with cadmium
分子名称: ACETATE ION, Amyloid beta A4 protein, CADMIUM ION
著者Dahms, S.O, Konnig, I, Roeser, D, Guhrs, K.H, Than, M.E.
登録日2011-11-13
公開日2012-01-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
J.Mol.Biol., 416, 2012
7JXN
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Beta hairpin derived from Abeta17-36 with an F20Cha mutation
分子名称: Amyloid-beta 17-36 peptide, CHLORIDE ION, SODIUM ION
著者Kreutzer, A.G, Haerianardakani, S, Nowick, J.S.
登録日2020-08-27
公開日2020-12-09
最終更新日2020-12-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Phenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by beta-Hairpins Derived from A beta.
J.Am.Chem.Soc., 142, 2020
3MXC
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BU of 3mxc by Molmil
Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications.
分子名称: AICD peptide, Growth factor receptor-bound protein 2
著者Sen, U, Das, S.
登録日2010-05-07
公開日2011-05-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain.
J.Mol.Biol., 414, 2011
3AYU
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BU of 3ayu by Molmil
Crystal structure of MMP-2 active site mutant in complex with APP-drived decapeptide inhibitor
分子名称: 72 kDa type IV collagenase, Amyloid beta A4 protein, CALCIUM ION, ...
著者Hashimoto, H, Takeuchi, T, Komatsu, K, Miyazaki, K, Sato, M, Higashi, S.
登録日2011-05-17
公開日2011-08-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for matrix metalloproteinase-2 (MMP-2)-selective inhibitory action of {beta}-amyloid precursor protein-derived inhibitor
J.Biol.Chem., 2011
3DXE
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BU of 3dxe by Molmil
Crystal structure of the intracellular domain of human APP (T668A mutant) in complex with Fe65-PTB2
分子名称: Amyloid beta A4 protein, Amyloid beta A4 protein-binding family B member 1
著者Radzimanowski, J, Sinning, I, Wild, K.
登録日2008-07-24
公開日2008-09-16
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
Embo Rep., 9, 2008
3JQ5
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Phospholipase A2 Prevents the Aggregation of Amyloid Beta Peptides: Crystal Structure of the Complex of Phospholipase A2 with Octapeptide Fragment of Amyloid Beta Peptide, Asp-Ala-Glu-Phe-Arg-His-Asp-Ser at 2 A Resolution
分子名称: Amyloid Beta Peptide, CALCIUM ION, Phospholipase A2 isoform 3
著者Mirza, Z, Vikram, G, Singh, N, Sinha, M, Bhushan, A, Sharma, S, Srinivasan, A, Kaur, P, Singh, T.P.
登録日2009-09-06
公開日2009-09-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Phospholipase A2 Prevents the Aggregation of Amyloid Beta Peptides: Crystal Structure of the Complex of Phospholipase A2 with Octapeptide Fragment of Amyloid Beta Peptide, Asp-Ala-Glu-Phe-Arg-His-Asp-Ser at 2 A Resolution
To be Published
3GCI
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BU of 3gci by Molmil
Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution
分子名称: CALCIUM ION, Heptapeptide from Amyloid beta A4 protein, Phospholipase A2 isoform 3
著者Mirza, Z, Vikram, G, Singh, N, Sinha, M, Bhushan, A, Sharma, S, Srinivasan, A, Kaur, P, Singh, T.P.
登録日2009-02-22
公開日2009-03-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution
To be Published
3MOQ
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BU of 3moq by Molmil
Amyloid beta(18-41) peptide fusion with new antigen receptor variable domain from sharks
分子名称: New antigen receptor variable domain,P3(40) peptide from Amyloid beta A4 protein,New antigen receptor variable domain
著者Streltsov, V.A.
登録日2010-04-23
公開日2011-02-16
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.054 Å)
主引用文献Crystal Structure of the Amyloid-{beta} p3 Fragment Provides a Model for Oligomer Formation in Alzheimer's Disease
J.Neurosci., 31, 2011
7RTZ
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BU of 7rtz by Molmil
X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 14-40
分子名称: Amyloid-beta protein 40, CHLORIDE ION
著者Samdin, T.D, Kreutzer, A.G, Nowick, J.S.
登録日2021-08-16
公開日2022-08-31
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A beta-Barrel-Like Tetramer Formed by a beta-Hairpin Derived From A beta
Chem Sci, 2023
2Y3L
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BU of 2y3l by Molmil
Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 2
分子名称: AMYLOID BETA A4 PROTEIN
著者Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D.
登録日2010-12-21
公開日2011-11-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular Basis for Amyloid-{Beta} Polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
2G47
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BU of 2g47 by Molmil
Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40)
分子名称: 1,4-DIETHYLENE DIOXIDE, Insulin-degrading enzyme, amyloid protein beta A4
著者Shen, Y, Tang, W.-J.
登録日2006-02-21
公開日2006-10-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
3DXC
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BU of 3dxc by Molmil
Crystal structure of the intracellular domain of human APP in complex with Fe65-PTB2
分子名称: Amyloid beta A4 protein, Amyloid beta A4 protein-binding family B member 1
著者Radzimanowski, J, Sinning, I, Wild, K.
登録日2008-07-24
公開日2008-09-16
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
Embo Rep., 9, 2008
1CA0
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BU of 1ca0 by Molmil
BOVINE CHYMOTRYPSIN COMPLEXED TO APPI
分子名称: BOVINE CHYMOTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR
著者Scheidig, A.J, Kossiakoff, A.A.
登録日1997-01-23
公開日1997-07-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6, 1997
3IFO
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BU of 3ifo by Molmil
X-ray structure of amyloid beta peptide:antibody (Abeta1-7:10D5) complex
分子名称: 10D5 FAB antibody heavy chain, 10D5 FAB antibody light chain, Amyloid beta A4 protein
著者Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D.
登録日2009-07-24
公開日2009-11-17
最終更新日2013-09-25
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
6ITU
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BU of 6itu by Molmil
Crystal Structure of the GULP1 PTB domain-APP peptide complex
分子名称: 1,2-ETHANEDIOL, Amyloid beta A4 protein, PTB domain-containing engulfment adapter protein 1, ...
著者Yung, K.W.Y, Lau, K.F, Ngo, J.C.K.
登録日2018-11-26
公開日2019-08-14
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Attenuation of amyloid-beta generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.
Faseb J., 33, 2019
3DXD
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BU of 3dxd by Molmil
Crystal structure of the intracellular domain of human APP (T668E mutant) in complex with Fe65-PTB2
分子名称: Amyloid beta A4 protein, Amyloid beta A4 protein-binding family B member 1
著者Radzimanowski, J, Sinning, I, Wild, K.
登録日2008-07-24
公開日2008-09-16
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
Embo Rep., 9, 2008
4ONG
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BU of 4ong by Molmil
Fab fragment of 3D6 in complex with amyloid beta 1-40
分子名称: 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein, ...
著者Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S.
登録日2014-01-28
公開日2014-06-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab.
Alzheimers Res Ther, 6, 2014
4HIX
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BU of 4hix by Molmil
Crystal structure of a humanised 3D6 Fab bound to amyloid beta peptide
分子名称: Beta-amyloid protein 40, Humanized 3D6 Fab heavy chain, Humanized 3D6 Fab light chain
著者Miles, L.A, Crespi, G.A.N, Parker, M.W.
登録日2012-10-12
公開日2013-03-13
最終更新日2014-03-19
実験手法X-RAY DIFFRACTION (2.204 Å)
主引用文献Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation.
Sci Rep, 3, 2013
5MY4
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BU of 5my4 by Molmil
Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with human Abeta-pE3-12PEGb
分子名称: Fab c#17 heavy chain, Fab c#17 light chain, Pyroglutamate-Abeta pE3-12-PEGb
著者Parthier, C, Piechotta, A, Stubbs, M.T.
登録日2017-01-25
公開日2017-06-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.211 Å)
主引用文献Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292, 2017
5HOY
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BU of 5hoy by Molmil
X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. X-ray diffractometer data set. (LVFFAEDCGSNKCAII(SAR)LMV).
分子名称: Amyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500)
著者Kreutzer, A.G, Spencer, R.K, Nowick, J.S.
登録日2016-01-19
公開日2016-03-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.295 Å)
主引用文献X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin.
J.Am.Chem.Soc., 138, 2016
5HOW
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BU of 5how by Molmil
X-ray crystallographic structure of an Abeta 17-36 beta-hairpin. LV(PHI)FAEDCGSNKCAII(SAR)L(ORN)V
分子名称: Amyloid beta A4 protein
著者Kreutzer, A.G, Nowick, J.S, Spencer, R.K.
登録日2016-01-19
公開日2016-03-23
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (2.295 Å)
主引用文献X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin.
J.Am.Chem.Soc., 138, 2016
5NX3
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Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy
分子名称: Amyloid-beta A4 protein, Kallikrein-6
著者Shahar, A, Sananes, A, Radisky, E.S, Papo, N.
登録日2017-05-09
公開日2018-05-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.296 Å)
主引用文献A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
J.Biol.Chem., 293, 2018

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