3AYU
Crystal structure of MMP-2 active site mutant in complex with APP-drived decapeptide inhibitor
Summary for 3AYU
Entry DOI | 10.2210/pdb3ayu/pdb |
Descriptor | 72 kDa type IV collagenase, Amyloid beta A4 protein, ZINC ION, ... (5 entities in total) |
Functional Keywords | protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Secreted, extracellular space, extracellular matrix. Isoform 2: Cytoplasm: P08253 Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 2 |
Total formula weight | 20028.94 |
Authors | Hashimoto, H.,Takeuchi, T.,Komatsu, K.,Miyazaki, K.,Sato, M.,Higashi, S. (deposition date: 2011-05-17, release date: 2011-08-03, Last modification date: 2024-03-13) |
Primary citation | Hashimoto, H.,Takeuchi, T.,Komatsu, K.,Miyazaki, K.,Sato, M.,Higashi, S. Structural basis for matrix metalloproteinase-2 (MMP-2)-selective inhibitory action of {beta}-amyloid precursor protein-derived inhibitor J.Biol.Chem., 2011 Cited by PubMed: 21813640DOI: 10.1074/jbc.M111.264176 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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