3AYU
Crystal structure of MMP-2 active site mutant in complex with APP-drived decapeptide inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 72 kDa type IV collagenase | polymer | 167 | 18697.7 | 1 | UniProt (P08253) Pfam (PF00413) | Homo sapiens (human) | 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2 |
| 2 | B (B) | Amyloid beta A4 protein | polymer | 10 | 1080.2 | 1 | UniProt (P05067) | Homo sapiens | ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II |
| 3 | C, D (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, F, G (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 263 | Chemie (HOH) |
Sequence modifications
A: 1 - 110 (UniProt: P08253)
A: 111 - 167 (UniProt: P08253)
| PDB | External Database | Details |
|---|---|---|
| Lys 108 | Glu 217 | engineered mutation |
| Val 110 | Gln 219 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 121 | Glu 404 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 19777.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 251.1 | |
| All* | Total formula weight | 20028.9 |
