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PDB: 216 件
7WVY
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Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2
分子名称: Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
登録日2022-02-11
公開日2022-04-13
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
8X53
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Cryo-EM structure of human gamma-secretase in complex with Abeta46
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y.
登録日2023-11-16
公開日2024-05-29
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Molecular mechanism of substrate recognition and cleavage by human gamma-secretase.
Science, 384, 2024
8BFA
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Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure
分子名称: Amyloid-beta precursor protein
著者Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W.
登録日2022-10-24
公開日2023-05-31
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain.
Nat Commun, 14, 2023
8FF3
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Amyloid-beta (1-40) fibrils derived from familial Dutch-type CAA patient (population B)
分子名称: Amyloid-beta precursor protein
著者Crooks, E.J, Fu, Z, Chowdury, S, Smith, S.O.
登録日2022-12-07
公開日2023-12-06
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.09 Å)
主引用文献An electrostatic cluster guides A beta 40 fibril formation in sporadic and Dutch-type cerebral amyloid angiopathy.
J.Struct.Biol., 216, 2024
8I4O
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Design of a split green fluorescent protein for sensing and tracking an beta-amyloid
分子名称: Beta-amyloid, Split Green flourescent protein
著者Taegeun, Y, Jinsu, L, Jungmin, Y, Jungmin, C, Wondo, H, Song, J.J, Haksung, K.
登録日2023-01-20
公開日2023-11-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Engineering of a Fluorescent Protein for a Sensing of an Intrinsically Disordered Protein through Transition in the Chromophore State.
Jacs Au, 3, 2023
7F29
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Cryo-EM structure of the fibril formed by disaccharide-modified amyloid-beta(1-42)
分子名称: ACETIC ACID, Amyloid-beta A4 protein, beta-D-galactopyranose-(1-3)-2-amino-2-deoxy-alpha-D-galactopyranose
著者Xia, W.C, Sun, Y.P, Liu, C.
登録日2021-06-10
公開日2022-07-13
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献O-Glycosylation Induces Amyloid-beta To Form New Fibril Polymorphs Vulnerable for Degradation
J.Am.Chem.Soc., 143, 2021
8SEJ
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Type I beta-amyloid 42 Filaments from Down syndrome
分子名称: Amyloid-beta protein 42
著者Hoq, M.R, Bharath, S.R, Vago, F.S, Jiang, W.
登録日2023-04-10
公開日2024-04-03
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024
3NYJ
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BU of 3nyj by Molmil
Crystal Structure Analysis of APP E2 domain
分子名称: Amyloid beta A4 protein, OSMIUM ION
著者Ha, Y, Hu, J, Lee, S, Liu, X.
登録日2010-07-15
公開日2011-06-01
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization.
Biochemistry, 50, 2011
8BFB
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BU of 8bfb by Molmil
Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure (Methoxy-X04-labelled mice)
分子名称: Amyloid-beta precursor protein
著者Wilkinson, M, Leistner, C, Burgess, A, Goodfellow, S, Deuchars, S, Ranson, N.A, Radford, S.E, Frank, R.A.W.
登録日2022-10-24
公開日2023-05-31
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain.
Nat Commun, 14, 2023
8OVM
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Lipidic amyloid-beta(1-40) fibril - polymorph L2
分子名称: Amyloid-beta A4 protein
著者Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F.
登録日2023-04-26
公開日2024-03-06
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40).
Nat Commun, 15, 2024
8OWD
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Lipidic amyloid-beta(1-40) fibril - polymorph L3
分子名称: Amyloid-beta A4 protein
著者Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F.
登録日2023-04-27
公開日2024-03-06
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40).
Nat Commun, 15, 2024
8OLN
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BU of 8oln by Molmil
DI1 Abeta fibril from tg-SwDI mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
6XOV
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BU of 6xov by Molmil
CryoEM structure of human presequence protease in partial closed state 1
分子名称: Amyloid-beta precursor protein, Presequence protease, mitochondrial
著者Liang, W.G, Zhao, M, Tang, W.
登録日2020-07-07
公開日2021-07-07
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
Nat Commun, 13, 2022
8OTF
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BU of 8otf by Molmil
Ab typeII filament from Guam ALS/PDC
分子名称: Amyloid-beta precursor protein
著者Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
登録日2023-04-20
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Proc.Natl.Acad.Sci.USA, 120, 2023
3SV1
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BU of 3sv1 by Molmil
Crystal structure of APP peptide bound rat Mint2 PARM
分子名称: Amyloid beta A4 precursor protein-binding family A member 2, Amyloid beta A4 protein
著者Shen, Y, Long, J, Yan, X, Xie, X.
登録日2011-07-12
公開日2012-07-11
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Open-closed motion of Mint2 regulates APP metabolism
J Mol Cell Biol, 5, 2013
8OL5
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BU of 8ol5 by Molmil
Murine type II Abeta fibril from ARTE10 mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
7O1Q
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BU of 7o1q by Molmil
Amyloid beta oligomer displayed on the alpha hemolysin scaffold
分子名称: Alpha-hemolysin hybridized Abeta
著者Wu, J, Blum, T.B, Farrell, D.P, DiMaio, F, Abrahams, J.P, Luo, J.
登録日2021-03-30
公開日2021-04-14
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-electron Microscopy Imaging of Alzheimer's Amyloid-beta 42 Oligomer Displayed on a Functionally and Structurally Relevant Scaffold.
Angew.Chem.Int.Ed.Engl., 60, 2021
8SEK
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BU of 8sek by Molmil
Type IIIa beta-amyloid 40 Filaments from Down syndrome
分子名称: Type IIIb beta-amyloid 40 Filament
著者Hoq, M.R, Vago, F.S, Bharath, S.R, Jiang, W.
登録日2023-04-10
公開日2024-04-03
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024
8OL3
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BU of 8ol3 by Molmil
Murine type III Abeta fibril from APP/PS1 mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
8OLO
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BU of 8olo by Molmil
Murine type III Abeta fibril from ARTE10 mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023
4M1C
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BU of 4m1c by Molmil
Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40)
分子名称: Amyloid beta A4 protein, Fab-bound IDE, heavy chain, ...
著者McCord, L.M, Liang, W, Farcasanu, M, Scherpelz, K, Meredith, S.C, Koide, S, Tang, W.J.
登録日2013-08-02
公開日2014-08-06
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.5007 Å)
主引用文献Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40)
To be Published
8AZT
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BU of 8azt by Molmil
Type II amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42
分子名称: Amyloid-beta precursor protein
著者Yang, Y, Stern, M.A, Meunier, L.A, Liu, W, Cai, Y.Q, Ericsson, M, Liu, L, Selkoe, J.D, Goedert, M, Scheres, H.W.S.
登録日2022-09-06
公開日2022-11-02
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Abundant A beta fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains.
Neuron, 111, 2023
8OWJ
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BU of 8owj by Molmil
Lipidic amyloid-beta(1-40) fibril - polymorph L2-L2
分子名称: Amyloid-beta A4 protein
著者Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F.
登録日2023-04-28
公開日2024-03-06
実験手法ELECTRON MICROSCOPY (3.75 Å)
主引用文献Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40).
Nat Commun, 15, 2024
8OWE
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BU of 8owe by Molmil
Lipidic amyloid-beta(1-40) fibril - polymorph L2-L3
分子名称: Amyloid-beta A4 protein
著者Frieg, B, Han, M, Giller, K, Dienemann, C, Riedel, D, Becker, S, Andreas, L.B, Griesinger, C, Schroeder, G.F.
登録日2023-04-27
公開日2024-03-06
実験手法ELECTRON MICROSCOPY (3.75 Å)
主引用文献Cryo-EM structures of lipidic fibrils of amyloid-beta (1-40).
Nat Commun, 15, 2024
8OL6
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Murine type II Abeta fibril from tgAPPSwe mouse
分子名称: Amyloid-beta protein 42
著者Zielinski, M, Peralta Reyes, F.S, Gremer, L, Schemmert, S, Frieg, B, Willuweit, A, Donner, L, Elvers, M, Nilsson, L.N.G, Syvanen, S, Sehlin, D, Ingelsson, M, Willbold, D, Schroeder, G.F.
登録日2023-03-30
公開日2023-11-29
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Cryo-EM of A beta fibrils from mouse models find tg-APP ArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Nat.Neurosci., 26, 2023

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