8SEJ

Type I beta-amyloid 42 Filaments from Down syndrome

Summary for 8SEJ

• Entry DOI: 10.2210/pdb8sej/pdb
• EMDB information: 40416
• Descriptor: Amyloid-beta protein 42 (1 entity in total)
• Functional Keywords: beta amyloid filaments, down syndrome, neuropeptide, human trisomy 21
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 35601.28

Authors

Hoq, M.R.,Bharath, S.R.,Vago, F.S.,Jiang, W. (deposition date: 2023-04-10, release date: 2024-04-03, Last modification date: 2024-06-26)

• Primary citation: Fernandez, A.,Hoq, M.R.,Hallinan, G.I.,Li, D.,Bharath, S.R.,Vago, F.S.,Zhang, X.,Ozcan, K.A.,Newell, K.L.,Garringer, H.J.,Jiang, W.,Ghetti, B.,Vidal, R.; Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.; Nat.Struct.Mol.Biol., 31:903-909, 2024; PubMed: 38553642; DOI: 10.1038/s41594-024-01252-3

Experimental method

ELECTRON MICROSCOPY (3.17 Å)