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8SEJ

Type I beta-amyloid 42 Filaments from Down syndrome

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207
ChainResidueDetails
ATYR10
JTYR10
BTYR10
CTYR10
DTYR10
ETYR10
FTYR10
GTYR10
HTYR10
ITYR10

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943
ChainResidueDetails
AHIS13
JHIS13
BHIS13
CHIS13
DHIS13
EHIS13
FHIS13
GHIS13
HHIS13
IHIS13

site_idSWS_FT_FI3
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943
ChainResidueDetails
AHIS14
JHIS14
BHIS14
CHIS14
DHIS14
EHIS14
FHIS14
GHIS14
HHIS14
IHIS14

site_idSWS_FT_FI4
Number of Residues10
DetailsSITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430
ChainResidueDetails
ALYS16
JLYS16
BLYS16
CLYS16
DLYS16
ELYS16
FLYS16
GLYS16
HLYS16
ILYS16

site_idSWS_FT_FI5
Number of Residues10
DetailsSITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112
ChainResidueDetails
APHE19
JPHE19
BPHE19
CPHE19
DPHE19
EPHE19
FPHE19
GPHE19
HPHE19
IPHE19

site_idSWS_FT_FI6
Number of Residues10
DetailsSITE: Implicated in free radical propagation => ECO:0000250
ChainResidueDetails
AGLY33
JGLY33
BGLY33
CGLY33
DGLY33
EGLY33
FGLY33
GGLY33
HGLY33
IGLY33

site_idSWS_FT_FI7
Number of Residues10
DetailsSITE: Susceptible to oxidation => ECO:0000269|PubMed:10535332
ChainResidueDetails
AMET35
JMET35
BMET35
CMET35
DMET35
EMET35
FMET35
GMET35
HMET35
IMET35

site_idSWS_FT_FI8
Number of Residues10
DetailsSITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305|PubMed:11851430
ChainResidueDetails
AVAL40
JVAL40
BVAL40
CVAL40
DVAL40
EVAL40
FVAL40
GVAL40
HVAL40
IVAL40

site_idSWS_FT_FI9
Number of Residues10
DetailsSITE: Cleavage; by gamma-secretase; site 2 => ECO:0000305|PubMed:11851430
ChainResidueDetails
AALA42
JALA42
BALA42
CALA42
DALA42
EALA42
FALA42
GALA42
HALA42
IALA42

site_idSWS_FT_FI10
Number of Residues10
DetailsCARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872
ChainResidueDetails
ATYR10
JTYR10
BTYR10
CTYR10
DTYR10
ETYR10
FTYR10
GTYR10
HTYR10
ITYR10

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PDB entries from 2024-07-10

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