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PDB: 49 件
4DRI
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BU of 4dri by Molmil
Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, Serine/threonine-protein kinase mTOR
著者Maerz, A.M, Bracher, A, Hausch, F.
登録日2012-02-17
公開日2013-02-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin.
Mol.Cell.Biol., 33, 2013
5GPG
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BU of 5gpg by Molmil
Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB domain of human mTOR
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP3, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, Serine/threonine-protein kinase mTOR
著者Lee, H.B, Lee, S.Y, Rhee, H.W, Lee, C.W.
登録日2016-08-02
公開日2016-10-12
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells
Acs Cent.Sci., 2, 2016
5WBH
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BU of 5wbh by Molmil
Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1
分子名称: Ribosomal protein S6 kinase beta-1, Serine/threonine-protein kinase mTOR
著者Pavletich, N.P, Yang, H.
登録日2017-06-29
公開日2017-12-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
4DRJ
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BU of 4drj by Molmil
o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP4, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, SULFATE ION, ...
著者Maerz, A.M, Bracher, A, Hausch, F.
登録日2012-02-17
公開日2013-02-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin.
Mol.Cell.Biol., 33, 2013
8PPZ
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BU of 8ppz by Molmil
Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
分子名称: (1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-[(~{E})-2-(2-chlorophenyl)ethenyl]-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one, ACETATE ION, CALCIUM ION, ...
著者Meyners, C, Deutscher, R.C.E, Hausch, F.
登録日2023-07-10
公開日2023-08-09
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR
Chemrxiv, 2023
3FAP
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BU of 3fap by Molmil
ATOMIC STRUCTURES OF THE RAPAMYCIN ANALOGS IN COMPLEX WITH BOTH HUMAN FKBP12 AND FRB DOMAIN OF FRAP
分子名称: C15-(R)-METHYLTHIENYL RAPAMYCIN, FK506-BINDING PROTEIN, FKBP12-RAPAMYCIN ASSOCIATED PROTEIN
著者Liang, J, Clardy, J.
登録日1999-05-06
公開日2000-09-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
6M4U
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Crystal structure of FKBP-FRB T2098L mutant in complex with rapamycin
分子名称: CHLORIDE ION, GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Kikuchi, M, Wu, D, Inoue, T, Umehara, T.
登録日2020-03-09
公開日2020-08-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Rational design and implementation of a chemically inducible heterotrimerization system.
Nat.Methods, 17, 2020
1NSG
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BU of 1nsg by Molmil
THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP
分子名称: C49-METHYL RAPAMYCIN, FK506-BINDING PROTEIN, FKBP-RAPAMYCIN ASSOCIATED PROTEIN (FRAP)
著者Liang, J, Choi, J, Clardy, J.
登録日1997-07-01
公開日1998-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
2FAP
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BU of 2fap by Molmil
THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-(C16)-ETHOXY RAPAMYCIN COMPLEX INTERACTING WITH HUMA
分子名称: C49-METHYL RAPAMYCIN, FK506-BINDING PROTEIN, FRAP
著者Liang, J, Choi, J, Clardy, J.
登録日1998-09-22
公開日1999-05-18
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
4DRH
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BU of 4drh by Molmil
Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR at low pH
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, SULFATE ION, ...
著者Maerz, A.M, Bracher, A, Hausch, F.
登録日2012-02-17
公開日2013-02-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin.
Mol.Cell.Biol., 33, 2013
1AUE
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BU of 1aue by Molmil
FKBP-RAPAMYCIN BINDING DOMAIN (FRB) OF THE FKBP-RAPAMYCIN ASSOCIATED PROTEIN
分子名称: FKBP-RAPAMYCIN ASSOCIATED PROTEIN
著者Odagaki, Y, Clardy, J.
登録日1997-08-25
公開日1998-10-28
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Structural Basis for Peptidomimicry by the Effector Element of Rapamycin
J.Am.Chem.Soc., 119, 1997
1FAP
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BU of 1fap by Molmil
THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP
分子名称: FK506-BINDING PROTEIN, FRAP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
著者Choi, J, Chen, J, Schreiber, S.L, Clardy, J.
登録日1996-03-15
公開日1997-07-23
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.
Science, 273, 1996
4FAP
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BU of 4fap by Molmil
ATOMIC STRUCTURES OF THE RAPAMYCIN ANALOGS IN COMPLEX WITH BOTH HUMAN FKBP12 AND FRB DOMAIN OF FRAP
分子名称: C15-(R)-METHYLTHIENYL RAPAMYCIN, FK506-BINDING PROTEIN, FKBP12-RAPAMYCIN ASSOCIATED PROTEIN
著者Liang, J, Clardy, J.
登録日1999-05-06
公開日2000-09-13
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
8ER6
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BU of 8er6 by Molmil
FKBP12-FRB in Complex with Compound 11
分子名称: (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1,2-ETHANEDIOL, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Tomlinson, A.C.A, Yano, J.K.
登録日2022-10-11
公開日2022-12-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J.Med.Chem., 66, 2023
8ERA
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BU of 8era by Molmil
RMC-5552 in complex with mTORC1 and FKBP12
分子名称: (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Tomlinson, A.C.A, Yano, J.K.
登録日2022-10-11
公開日2022-12-28
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J.Med.Chem., 66, 2023
6ZWO
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BU of 6zwo by Molmil
cryo-EM structure of human mTOR complex 2, focused on one half
分子名称: ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
著者Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T.
登録日2020-07-28
公開日2020-11-18
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献The 3.2- angstrom resolution structure of human mTORC2.
Sci Adv, 6, 2020
8ER7
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BU of 8er7 by Molmil
FKBP12-FRB in Complex with Compound 12
分子名称: (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-5,10,21-trimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Tomlinson, A.C.A, Yano, J.K.
登録日2022-10-11
公開日2022-12-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.07 Å)
主引用文献Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J.Med.Chem., 66, 2023
5WBY
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BU of 5wby by Molmil
Crystal structure of mTOR(deltaN)-mLST8-PRAS40(beta-strand) complex
分子名称: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8
著者Pavletich, N.P, Yang, H.
登録日2017-06-29
公開日2017-12-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
6M4W
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Crystal structure of MBP fused split FKBP-FRB T2098L mutant in complex with rapamycin
分子名称: GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP1A, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, ...
著者Kikuchi, M, Wu, D, Inoue, T, Umehara, T.
登録日2020-03-09
公開日2020-08-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Rational design and implementation of a chemically inducible heterotrimerization system.
Nat.Methods, 17, 2020
7PE8
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BU of 7pe8 by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer
分子名称: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ...
著者Waelchli, M, Maier, T.
登録日2021-08-09
公開日2021-09-08
最終更新日2021-09-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7UXH
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BU of 7uxh by Molmil
cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Cui, Z, Hurley, J.
登録日2022-05-05
公開日2022-11-30
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Nature, 614, 2023
6ZWM
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cryo-EM structure of human mTOR complex 2, overall refinement
分子名称: ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
著者Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T.
登録日2020-07-28
公開日2020-11-18
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献The 3.2- angstrom resolution structure of human mTORC2.
Sci Adv, 6, 2020
7UXC
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BU of 7uxc by Molmil
cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex with symmetry expansion
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Cui, Z, Hurley, J.
登録日2022-05-05
公開日2022-11-30
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Nature, 614, 2023
4JSN
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structure of mTORdeltaN-mLST8 complex
分子名称: Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8
著者Pavletich, N.P.
登録日2013-03-22
公開日2013-05-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
6BCX
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mTORC1 structure refined to 3.0 angstroms
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, ...
著者Pavletich, N.P, Yang, H.
登録日2017-10-20
公開日2017-12-20
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017

 

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