2FAP
THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-(C16)-ETHOXY RAPAMYCIN COMPLEX INTERACTING WITH HUMA
Summary for 2FAP
Entry DOI | 10.2210/pdb2fap/pdb |
Descriptor | FK506-BINDING PROTEIN, FRAP, C49-METHYL RAPAMYCIN, ... (4 entities in total) |
Functional Keywords | fkbp12, frap, rapamycin, complex (isomerase-kinase), complex (isomerase-kinase) complex, complex (isomerase/kinase) |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P62942 Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P42345 |
Total number of polymer chains | 2 |
Total formula weight | 24096.64 |
Authors | Liang, J.,Choi, J.,Clardy, J. (deposition date: 1998-09-22, release date: 1999-05-18, Last modification date: 2023-08-09) |
Primary citation | Liang, J.,Choi, J.,Clardy, J. Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. Acta Crystallogr.,Sect.D, 55:736-744, 1999 Cited by PubMed: 10089303DOI: 10.1107/S0907444998014747 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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