1FAP

THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP

Summary for 1FAP

Entry DOI	10.2210/pdb1fap/pdb
Descriptor	FK506-BINDING PROTEIN, FRAP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, ... (4 entities in total)
Functional Keywords	fkbp12, frap, rapamycin, complex (isomerase-kinase), complex (isomerase-kinase) complex, complex (isomerase/kinase)
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	24239.81
Authors	Choi, J.,Chen, J.,Schreiber, S.L.,Clardy, J. (deposition date: 1996-03-15, release date: 1997-07-23, Last modification date: 2024-02-07)
Primary citation	Choi, J.,Chen, J.,Schreiber, S.L.,Clardy, J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science, 273:239-242, 1996 Cited by PubMed: 8662507 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation