4DRJ
o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
Summary for 4DRJ
Entry DOI | 10.2210/pdb4drj/pdb |
Related | 4DRI 4DRJ |
Descriptor | Peptidyl-prolyl cis-trans isomerase FKBP4, Serine/threonine-protein kinase mTOR, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, ... (5 entities in total) |
Functional Keywords | fk-506 binding domain, hsp90 cochaperone, immunophilin, peptidyl-prolyl isomerase, kinase, signalling, mammalian target of rapamycin, immunosuppression, cancer, isomerase-transferase complex, isomerase/transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm, cytosol (By similarity): Q02790 Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P42345 |
Total number of polymer chains | 2 |
Total formula weight | 28410.50 |
Authors | Maerz, A.M.,Bracher, A.,Hausch, F. (deposition date: 2012-02-17, release date: 2013-02-06, Last modification date: 2023-09-13) |
Primary citation | Marz, A.M.,Fabian, A.K.,Kozany, C.,Bracher, A.,Hausch, F. Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin. Mol.Cell.Biol., 33:1357-1367, 2013 Cited by PubMed: 23358420DOI: 10.1128/MCB.00678-12 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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