4DRJ
o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Peptidyl-prolyl cis-trans isomerase FKBP4 | polymer | 144 | 15652.9 | 1 | UniProt (Q02790) Pfam (PF00254) In PDB | Homo sapiens (human) | PPIase FKBP4, 51 kDa FK506-binding protein, FKBP51, 52 kDa FK506-binding protein, 52 kDa FKBP, FKBP-52, 59 kDa immunophilin, p59, FK506-binding protein 4, FKBP-4, FKBP59, HSP-binding immunophilin, HBI, Immunophilin FKBP52, Rotamase, Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed |
2 | B | Serine/threonine-protein kinase mTOR | polymer | 98 | 11747.4 | 1 | UniProt (P42345) Pfam (PF08771) In PDB | Homo sapiens (human) | FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1 |
3 | A | RAPAMYCIN IMMUNOSUPPRESSANT DRUG | non-polymer | 914.2 | 1 | Chemie (RAP) | |||
4 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
5 | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A: 1 - 140 (UniProt: Q02790)
B: 2025 - 2114 (UniProt: P42345)
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Ala -2 | - | expression tag |
Met -1 | - | expression tag |
Gly 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 2017 | - | expression tag |
Ala 2018 | - | expression tag |
Met 2019 | - | expression tag |
Asp 2020 | - | expression tag |
Pro 2021 | - | expression tag |
Glu 2022 | - | expression tag |
Phe 2023 | - | expression tag |
Met 2024 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 27400.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1010.2 | |
All* | Total formula weight | 28410.5 |