7LWO
 
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8TYL
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8ASY
 | | SARS-CoV-2 Omicron BA.2.75 RBD in complex with ACE2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | | 著者 | Zhou, D, Huo, J, Ren, J, Stuart, D.I. | | 登録日 | 2022-08-22 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75.
Cell Rep, 42, 2022
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7FBJ
 | | Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing nanobody 17F6 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, New antigen receptor variable domain, ... | | 著者 | Zhu, J, Xu, T, Feng, B, Liu, J. | | 登録日 | 2021-07-11 | | 公開日 | 2022-07-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape.
Small Methods, 6, 2022
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7Y9Z
 | | Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with human ACE2 ectodomain (one-RBD-up state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | | 著者 | Gao, G.F, Qi, J.X, Liu, S, Zhao, Z.N. | | 登録日 | 2022-06-26 | | 公開日 | 2022-09-21 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.
Nat Commun, 13, 2022
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8GF2
 | | Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies eCR3022.20 and CC12.3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.3 Fab heavy chain, ... | | 著者 | Yuan, M, Zhu, X, Wilson, I.A. | | 登録日 | 2023-03-07 | | 公開日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.851 Å) | | 主引用文献 | Broadening a SARS-CoV-1-neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution.
Sci.Signal., 16, 2023
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8HN4
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8Y0Y
 | | Cryo-EM structure of the 123-316 scDb/PT-RBD complex | | 分子名称: | 123-316 scDb, 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Jia, G.W, Tong, Z, Tong, J.Y, Su, Z.M. | | 登録日 | 2024-01-23 | | 公開日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1, and JN.1.
Cell Rep, 43, 2024
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7S5P
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8HRD
 | | Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IMCAS74 Fab heavy chain, IMCAS74 Fab light chain, ... | | 著者 | Zhao, R.C, Wu, L.L, Han, P. | | 登録日 | 2022-12-15 | | 公開日 | 2023-12-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | | 主引用文献 | Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8GS6
 | | Structure of the SARS-CoV-2 BA.2.75 spike glycoprotein (closed state 1) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Anraku, Y, Tabata-Sasaki, K, Kita, S, Fukuhara, H, Maenaka, K, Hashiguchi, T. | | 登録日 | 2022-09-05 | | 公開日 | 2022-10-26 | | 最終更新日 | 2023-03-29 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant.
Cell Host Microbe, 30, 2022
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7V20
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8XN5
 | | Cryo-EM structure of SARS-CoV-2 Omicron EG.5.1 spike protein(6P) in complex with human ACE2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ... | | 著者 | Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F. | | 登録日 | 2023-12-29 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | | 主引用文献 | Structural basis of receptor binding and immune escape for SARS-CoV-2 Omicron BA.2.86, EG.5, EG.5.1 and HV.1 sub-variants
To Be Published
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7S5Q
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8BG1
 | | Crystal structure of the SARS-CoV-2 S RBD in complex with pT1511 scFV | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Hansen, G, Ssebyatika, G.L, Krey, T. | | 登録日 | 2022-10-27 | | 公開日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | | 主引用文献 | Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses?
To be published
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7XSC
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7C01
 | | Molecular basis for a potent human neutralizing antibody targeting SARS-CoV-2 RBD | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CB6 heavy chain, CB6 light chain, ... | | 著者 | Shi, R, Qi, J, Wang, Q, Gao, F.G, Yan, J. | | 登録日 | 2020-04-29 | | 公開日 | 2020-05-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | | 主引用文献 | A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2.
Nature, 584, 2020
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7KQE
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6XC7
 | | Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CC12.3 and CR3022 | | 分子名称: | CC12.3 heavy chain, CC12.3 light chain, CR3022 heavy chain, ... | | 著者 | Yuan, M, Liu, H, Wu, N.C, Zhu, X, Wilson, I.A. | | 登録日 | 2020-06-08 | | 公開日 | 2020-07-08 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.883 Å) | | 主引用文献 | Structural basis of a shared antibody response to SARS-CoV-2.
Science, 369, 2020
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8WP8
 | | Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 RBD in complex with human ACE2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | | 著者 | Li, L.J, Gu, Y.H, Qi, J.X, Gao, G.F. | | 登録日 | 2023-10-09 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 RBD in complex with human ACE2
To Be Published
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7VMU
 | | Crystal Structure of SARS-CoV Spike Receptor-Binding Domain Complexed with Neutralizing Antibody | | 分子名称: | Spike protein S1, scFv E4 | | 著者 | Guo, Y, Wang, W, Jiao, P, Yang, H, Rao, Z, Cheng, G. | | 登録日 | 2021-10-09 | | 公開日 | 2021-11-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants.
Cell Biosci, 12, 2022
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7NLL
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8EL2
 | | SARS-CoV-2 RBD bound to neutralizing antibody Fab ICO-hu23 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab ICO-hu23 Heavy Chain, Fab ICO-hu23 Light Chain, ... | | 著者 | Besaw, J.E, Kuo, A, Morizumi, T, Ernst, O.P. | | 登録日 | 2022-09-22 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates.
Plos Pathog., 19, 2023
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7JMW
 | | Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with cross-neutralizing antibody COVA1-16 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVA1-16 heavy chain, COVA1-16 light chain, ... | | 著者 | Liu, H, Yuan, M, Zhu, X, Wu, N.C, Wilson, I.A. | | 登録日 | 2020-08-03 | | 公開日 | 2020-10-14 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity.
Immunity, 53, 2020
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7QEZ
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