8GS6
Structure of the SARS-CoV-2 BA.2.75 spike glycoprotein (closed state 1)
Summary for 8GS6
| Entry DOI | 10.2210/pdb8gs6/pdb |
| EMDB information | 34221 |
| Descriptor | Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
| Functional Keywords | spike glycoprotein, viral protein |
| Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) |
| Total number of polymer chains | 3 |
| Total formula weight | 423976.81 |
| Authors | Anraku, Y.,Tabata-Sasaki, K.,Kita, S.,Fukuhara, H.,Maenaka, K.,Hashiguchi, T. (deposition date: 2022-09-05, release date: 2022-10-26, Last modification date: 2024-10-16) |
| Primary citation | Saito, A.,Tamura, T.,Zahradnik, J.,Deguchi, S.,Tabata, K.,Anraku, Y.,Kimura, I.,Ito, J.,Yamasoba, D.,Nasser, H.,Toyoda, M.,Nagata, K.,Uriu, K.,Kosugi, Y.,Fujita, S.,Shofa, M.,Monira Begum, M.,Shimizu, R.,Oda, Y.,Suzuki, R.,Ito, H.,Nao, N.,Wang, L.,Tsuda, M.,Yoshimatsu, K.,Kuramochi, J.,Kita, S.,Sasaki-Tabata, K.,Fukuhara, H.,Maenaka, K.,Yamamoto, Y.,Nagamoto, T.,Asakura, H.,Nagashima, M.,Sadamasu, K.,Yoshimura, K.,Ueno, T.,Schreiber, G.,Takaori-Kondo, A.,Shirakawa, K.,Sawa, H.,Irie, T.,Hashiguchi, T.,Takayama, K.,Matsuno, K.,Tanaka, S.,Ikeda, T.,Fukuhara, T.,Sato, K. Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant. Cell Host Microbe, 30:1540-1555.e15, 2022 Cited by PubMed Abstract: The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We determined the sensitivity of BA.2.75 to vaccinee and convalescent sera as well as a panel of clinically available antiviral drugs and antibodies. Antiviral drugs largely retained potency, but antibody sensitivity varied depending on several key BA.2.75-specific substitutions. The BA.2.75 spike exhibited a profoundly higher affinity for its human receptor, ACE2. Additionally, the fusogenicity, growth efficiency in human alveolar epithelial cells, and intrinsic pathogenicity in hamsters of BA.2.75 were greater than those of BA.2. Our multilevel investigations suggest that BA.2.75 acquired virological properties independent of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5. PubMed: 36272413DOI: 10.1016/j.chom.2022.10.003 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.86 Å) |
Structure validation
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