8GWF
 
 | | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... | | 著者 | Yan, L.Y, Huang, Y.C, Rao, Z.H, Lou, Z.Y. | | 登録日 | 2022-09-17 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors.
Cell, 185, 2022
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6XQB
 | | SARS-CoV-2 RdRp/RNA complex | | 分子名称: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Liu, B, Shi, W, Yang, Y. | | 登録日 | 2020-07-09 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure of SARS-CoV-2 RdRp/RNA complex at 3.4 Angstroms resolution
To Be Published
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7N0C
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7B3C
 | | Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -4 (structure 2) | | 分子名称: | DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*A)-D(P*(RMP))-R(P*GP*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | | 登録日 | 2020-11-30 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.
Nat Commun, 12, 2021
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7KRN
 | | Structure of SARS-CoV-2 backtracked complex bound to nsp13 helicase - nsp13(1)-BTC | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | | 登録日 | 2020-11-20 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7TQV
 | | SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA | | 分子名称: | RNA (33-MER), Uridylate-specific endoribonuclease | | 著者 | Frazier, M.N, Krahn, J.M, Butay, K.J, Dillard, L.B, Borgnia, M.J, Stanley, R.E. | | 登録日 | 2022-01-27 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | | 主引用文献 | Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease.
Nucleic Acids Res., 50, 2022
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8EY2
 | | Cryo-EM structure of SARS-CoV-2 Main protease C145S in complex with N-terminal peptide | | 分子名称: | 3C-like proteinase | | 著者 | Noske, G.D, Song, Y, Fernandes, R.S, Oliva, G, Godoy, A.S. | | 登録日 | 2022-10-26 | | 公開日 | 2022-12-07 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition.
Nat Commun, 14, 2023
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7RE0
 | | SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - swiveled class | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Helicase, ... | | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | | 登録日 | 2021-07-12 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex.
Nat.Struct.Mol.Biol., 29, 2022
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6XEZ
 | | Structure of SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | | 著者 | Chen, J, Malone, B, Llewellyn, E.C, Campbell, E.A, Darst, S.A. | | 登録日 | 2020-06-14 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex.
Cell, 182, 2020
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7S82
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7RDZ
 | | SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - apo class | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Helicase, MAGNESIUM ION, ... | | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | | 登録日 | 2021-07-12 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex.
Nat.Struct.Mol.Biol., 29, 2022
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7KRO
 | | Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - nsp13(2)-BTC | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | | 著者 | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | | 登録日 | 2020-11-20 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7BW4
 | | Structure of the RNA-dependent RNA polymerase from SARS-CoV-2 | | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ... | | 著者 | Peng, Q, Peng, R, Shi, Y. | | 登録日 | 2020-04-13 | | 公開日 | 2020-05-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2.
Cell Rep, 31, 2020
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7MSW
 | | Full length SARS-CoV-2 Nsp2 | | 分子名称: | Non-structural protein 2, ZINC ION | | 著者 | QCRG Structural Biology Consortium | | 登録日 | 2021-05-12 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | | 主引用文献 | CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
To Be Published
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8GWO
 | | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors | | 分子名称: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | | 登録日 | 2022-09-17 | | 公開日 | 2022-11-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors.
Cell, 185, 2022
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7C33
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7CXN
 | | Architecture of a SARS-CoV-2 mini replication and transcription complex | | 分子名称: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | | 登録日 | 2020-09-02 | | 公開日 | 2020-11-04 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | | 主引用文献 | Architecture of a SARS-CoV-2 mini replication and transcription complex.
Nat Commun, 11, 2020
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7L1F
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7N0B
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8YB5
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8YB7
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8YAX
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7OYG
 | | Dimeric form of SARS-CoV-2 RNA-dependent RNA polymerase | | 分子名称: | RNA (5'-R(P*CP*UP*AP*CP*GP*CP*AP*GP*UP*G)-3'), RNA (5'-R(P*UP*GP*CP*AP*CP*UP*GP*CP*GP*UP*AP*G)-3'), SARS-CoV-2 RNA-dependent RNA polymerase (nsp12), ... | | 著者 | Jochheim, F.A, Tegunov, D, Hillen, H.S, Schmitzova, J, Kokic, G, Dienemann, C, Cramer, P. | | 登録日 | 2021-06-24 | | 公開日 | 2021-08-25 | | 最終更新日 | 2021-09-01 | | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | | 主引用文献 | The structure of a dimeric form of SARS-CoV-2 polymerase
Communications Biology, 4, 2021
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8GY6
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7LHQ
 | | Solution structure of SARS-CoV-2 nonstructural protein 7 at pH 7.0 | | 分子名称: | Non-structural protein 7 | | 著者 | Lee, Y, Tonelli, M, Anderson, T.K, Kirchdoerfer, R.N, Henzler-Wildman, K, Lee, W. | | 登録日 | 2021-01-26 | | 公開日 | 2022-02-09 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | pH-dependent polymorphism of the structure of SARS-CoV-2 nsp7
Biorxiv, 2021
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