8GWO

A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors

Summary for 8GWO

Entry DOI	10.2210/pdb8gwo/pdb
EMDB information	34318
Descriptor	RNA-directed RNA polymerase, URIDINE-5'-MONOPHOSPHATE, Non-structural protein 8, ... (10 entities in total)
Functional Keywords	sars-cov-2, capping, nucleotide analogue inhibitor, cryo-em, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	9
Total formula weight	326073.90
Authors	Yan, L.M.,Huang, Y.C.,Ge, J.,Liu, Z.Y.,Gao, Y.,Rao, Z.H.,Lou, Z.Y. (deposition date: 2022-09-17, release date: 2022-11-30, Last modification date: 2024-01-24)
Primary citation	Yan, L.,Huang, Y.,Ge, J.,Liu, Z.,Lu, P.,Huang, B.,Gao, S.,Wang, J.,Tan, L.,Ye, S.,Yu, F.,Lan, W.,Xu, S.,Zhou, F.,Shi, L.,Guddat, L.W.,Gao, Y.,Rao, Z.,Lou, Z. A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185:4347-4360.e17, 2022 Cited by PubMed: 36335936 DOI: 10.1016/j.cell.2022.09.037 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.8 Å)

Structure validation