8GWO
A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RNA-directed RNA polymerase | polymer | 932 | 106781.0 | 1 | UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) | Severe acute respiratory syndrome coronavirus 2 | Pol, RdRp, Non-structural protein 12, nsp12 |
| 2 | B, D (B, D) | Non-structural protein 8 | polymer | 198 | 21903.0 | 2 | UniProt (P0DTD1) Pfam (PF08717) | Severe acute respiratory syndrome coronavirus 2 | nsp8 |
| 3 | C (C) | Non-structural protein 7 | polymer | 83 | 9248.8 | 1 | UniProt (P0DTC1) Pfam (PF08716) UniProt (by SIFTS) (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 | nsp7 |
| 4 | E (I) | RNA (25-MER) | polymer | 25 | 8172.9 | 1 | synthetic construct | ||
| 5 | F (J) | template | polymer | 33 | 10443.2 | 1 | synthetic construct | ||
| 6 | G, H (F, E) | Helicase | polymer | 601 | 66930.5 | 2 | UniProt (P0DTD1) Pfam (PF20632) Pfam (PF20633) Pfam (PF20631) Pfam (PF13087) | Severe acute respiratory syndrome coronavirus 2 | Hel, Non-structural protein 13, nsp13 |
| 7 | I (G) | Non-structural protein 9 | polymer | 113 | 12391.2 | 1 | UniProt (P0DTD1) Pfam (PF08710) | Severe acute respiratory syndrome coronavirus 2 | nsp9 |
| 8 | J, K, M, N, O... (A, F, E) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 9 | L (A) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 10 | S (G) | URIDINE-5'-MONOPHOSPHATE | non-polymer | 324.2 | 1 | Chemie (U5P) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 324704.2 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1369.6 | |
| All* | Total formula weight | 326073.9 |
