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PDB: 461 件

6KVD
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Crystal structure of human nucleosome containing H2A.J
分子名称: CHLORIDE ION, DNA (146-MER), Histone H2A.J, ...
著者Tanaka, H, Koyama, M, Sato, S, Kujirai, T, Kurumizaka, H.
登録日2019-09-04
公開日2019-12-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Biochemical and structural analyses of the nucleosome containing human histone H2A.J.
J.Biochem., 167, 2020
6KE9
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The Human Telomeric Nucleosome Displays Distinct Structural and Dynamic Properties
分子名称: Histone H2A type 1-B/E, Histone H2B type 1-K, Histone H3.1, ...
著者Soman, A, Liew, C.W, Teo, H.L, Berezhnoy, N, Korolev, N, Rhodes, D, Nordenskiold, L.
登録日2019-07-04
公開日2020-04-22
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献The human telomeric nucleosome displays distinct structural and dynamic properties.
Nucleic Acids Res., 48, 2020
5NNC
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Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)
分子名称: Bromodomain-containing protein 4, Histone H3
著者Filippakopoulos, P, Picaud, S, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C.
登録日2017-04-08
公開日2018-05-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Mol. Cell, 73, 2019
7X88
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Crystal structure of ENL YEATS domain T2 mutant in complex with histone H3 acetylation at K27
分子名称: CITRIC ACID, Histone H3K27ac(24-27) peptide, Protein ENL
著者Li, Y.Y, Li, H.T.
登録日2022-03-11
公開日2023-01-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.
Mol.Cell, 82, 2022
6JXD
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BU of 6jxd by Molmil
Human nucleosome core particle with cohesive end DNA termini
分子名称: DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ...
著者DeFalco, L, Davey, C.A.
登録日2019-04-23
公開日2020-01-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome.
Nat Commun, 10, 2019
5XFR
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Ternary complex of MTF2, DNA and histone
分子名称: DNA (5'-D(*GP*GP*GP*CP*GP*GP*CP*CP*GP*CP*CP*CP*T)-3'), Metal-response element-binding transcription factor 2, Peptide from Histone H3.1, ...
著者Wang, Z, Li, H.
登録日2017-04-11
公開日2017-09-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Polycomb-like proteins link the PRC2 complex to CpG islands
Nature, 549, 2017
6IQ4
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Nucleosome core particle cross-linked with a hetero-binuclear molecule possessing RAPTA and gold(I) 4-(diphenylphosphino)benzoic acid groups.
分子名称: 4-diphenylphosphanylbenzoic acid, DNA (145-MER), GOLD ION, ...
著者DeFalco, L, Batchelor, L.K, Adhireksan, Z, Dyson, P.J, Davey, C.A.
登録日2018-11-06
公開日2019-10-30
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crosslinking Allosteric Sites on the Nucleosome.
Angew.Chem.Int.Ed.Engl., 58, 2019
2CO0
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WDR5 and unmodified Histone H3 complex at 2.25 Angstrom
分子名称: HISTONE H3 DIMETHYL-LYSINE 4, WD-REPEAT PROTEIN 5
著者Ruthenburg, A.J, Wang, W, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L.
登録日2006-05-25
公開日2006-07-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Histone H3 Recognition and Presentation by the Wdr5 Module of the Mll1 Complex
Nat.Struct.Mol.Biol., 13, 2006
6WW4
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Crystal structure of HERC2 ZZ domain in complex with histone H3 tail
分子名称: GLYCEROL, Histone H3.1,E3 ubiquitin-protein ligase HERC2, ZINC ION
著者Liu, J, Vann, K.R, Kutateladze, T.G.
登録日2020-05-07
公開日2020-08-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.252 Å)
主引用文献Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1.
Structure, 28, 2020
5KJH
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Crystal structure of an active polycomb repressive complex 2 in the stimulated state
分子名称: Peptide H3K27me3, Putative uncharacterized protein,Zinc finger domain-containing protein, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Jiao, L, Liu, X.
登録日2016-06-20
公開日2017-04-19
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354, 2016
5M5G
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Crystal structure of the Chaetomium Thermophilum polycomb repressive complex 2 (PRC2)
分子名称: Fragment from molecular 2 (region containing putative polycomb protein Suz12), HISTONE H3 11-Mer peptide, Putative uncharacterized protein, ...
著者Zhang, Y, Justin, N, Wilson, J, Gamblin, S.
登録日2016-10-21
公開日2017-01-11
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354, 2016
5WFC
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Humanized mutant of the Chaetomium thermophilum Polycomb Repressive Complex 2 bound to the inhibitor GSK343
分子名称: Histone H3.1, Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera, ...
著者Bratkowski, M.A, Liu, X.
登録日2017-07-11
公開日2018-06-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.282 Å)
主引用文献An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors.
Sci Rep, 8, 2018
5D6Y
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Crystal structure of double tudor domain of human lysine demethylase KDM4A complexed with histone H3K23me3
分子名称: Lysine-specific demethylase 4A, peptide H3K23me3 (19-28)
著者Wang, F, Su, Z, Miller, M.D, Denu, J.M, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
登録日2015-08-13
公開日2016-02-10
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (2.287 Å)
主引用文献Reader domain specificity and lysine demethylase-4 family function.
Nat Commun, 7, 2016
3A1B
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Crystal structure of the DNMT3A ADD domain in complex with histone H3
分子名称: 1,2-ETHANEDIOL, DNA (cytosine-5)-methyltransferase 3A, Histone H3.1, ...
著者Otani, J, Arita, K, Ariyoshi, M, Shirakawa, M.
登録日2009-03-28
公開日2009-11-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.292 Å)
主引用文献Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain
Embo Rep., 10, 2009
4C1Q
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BU of 4c1q by Molmil
Crystal structure of the PRDM9 SET domain in complex with H3K4me2 and AdoHcy.
分子名称: GLYCEROL, HISTONE H3.1, HISTONE-LYSINE N-METHYLTRANSFERASE PRDM9, ...
著者Mathioudakis, N, Cusack, S, Kadlec, J.
登録日2013-08-13
公開日2013-10-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of Prdm9.
Cell Rep., 5, 2013
8I60
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BU of 8i60 by Molmil
Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr
分子名称: ALA-ARG-KCR-SER-ALA-PRO, GLYCEROL, SULFATE ION, ...
著者Konuma, T, Zhou, M.-M.
登録日2023-01-26
公開日2023-07-26
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin.
Mol.Cell, 83, 2023
7X8B
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Crystal structure of ENL T1 mutant YEATS domain in complex with histone H3 acetylation at K27
分子名称: H3K27ac(24-27) peptide, Protein ENL
著者Li, Y, Peng, B, Li, H.
登録日2022-03-11
公開日2023-01-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.
Mol.Cell, 82, 2022
3QJ6
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BU of 3qj6 by Molmil
The crystal structure of PWWP domain of human Hepatoma-derived growth factor 2 in complex with H3K79me3 peptide
分子名称: H3K79me3, Hepatoma-derived growth factor-related protein 2, SULFATE ION, ...
著者Zeng, H, Amaya, M.F, Tempel, W, Walker, J.R, Mackenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC)
登録日2011-01-28
公開日2011-02-23
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and Histone Binding Ability Characterizations of Human PWWP Domains.
Plos One, 6, 2011
8Q3X
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Structure of Nucleosome Core with a Bound Metallopeptide Conjugate (Kaposi Sarcoma Associated Herpesvirus LANA Peptide-Au[I] Compound)
分子名称: 4-diphenylphosphanylbenzoic acid, DNA (145-MER), GOLD ION, ...
著者De Falco, L, Batchelor, L.K, Dyson, P.J, Davey, C.A.
登録日2023-08-04
公開日2024-03-27
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Viral peptide conjugates for metal-warhead delivery to chromatin.
Rsc Adv, 14, 2024
4N4H
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Crystal structure of the Bromo-PWWP of the mouse zinc finger MYND-type containing 11 isoform alpha in complex with histone H3.1K36me3
分子名称: DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, Peptide from Histone H3.1, ...
著者Li, Y, Ren, Y, Li, H.
登録日2013-10-08
公開日2014-03-05
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.302 Å)
主引用文献ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression
Nature, 508, 2014
4YHZ
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Crystal structure of 304M3-B Fab in complex with H3K4me3 peptide
分子名称: Fab Heavy Chain, Fab Light Chain, GLYCEROL, ...
著者Hattori, T, Dementieva, I.S, Montano, S.P, Koide, S.
登録日2015-02-27
公開日2016-02-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.304 Å)
主引用文献Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation.
Proc.Natl.Acad.Sci.USA, 113, 2016
6HGT
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Crystal structure of human KDM4A complexed with co-substrate analog NOG and histone H3 peptide with K9R mutation
分子名称: Histone H3.3, Lysine-specific demethylase 4A, N-OXALYLGLYCINE, ...
著者Maw, J, Le Bihan, Y.V, van Montfort, R.L.M.
登録日2018-08-23
公開日2019-09-04
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Structure-based design of selective, histone substrate-based inhibitors of histone lysine demethylases 4 (KDM4) subfamily
To be published
6IIS
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Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and an H3K36me3-containing histone peptide
分子名称: 16-bp TA-rich DNA, H3K36me3 peptide, Hepatoma-derived growth factor-related protein 3
著者Wang, Z, Tian, W.
登録日2018-10-07
公開日2019-04-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.358 Å)
主引用文献Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and an H3K36me3-containing histone peptide
Nucleic Acids Res., 2019
6AXJ
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Crystal structure of the Yaf9 YEATS domain bound to H3K27ac
分子名称: ALY-SER-ALA-PRO-ALA, GLYCEROL, Protein AF-9 homolog, ...
著者Klein, B.J, Kutateladze, T.G.
登録日2017-09-06
公開日2017-11-22
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.379 Å)
主引用文献Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain.
Nucleic Acids Res., 46, 2018
5VA6
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CRYSTAL STRUCTURE OF ATXR5 IN COMPLEX WITH HISTONE H3.1 MONO-METHYLATED ON R26
分子名称: Histone H3.1, Probable Histone-lysine N-methyltransferase ATXR5, S-ADENOSYL-L-HOMOCYSTEINE
著者Bergamin, E, Sarvan, S, Malette, J, Eram, M, Yeung, S, Mongeon, V, Joshi, M, Brunzelle, J.S, Michaels, S.D, Blais, A, Vedadi, M, Couture, J.-F.
登録日2017-03-24
公開日2017-04-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Molecular basis for the methylation specificity of ATXR5 for histone H3.
Nucleic Acids Res., 45, 2017

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件を2024-06-26に公開中

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