4YHZ

Crystal structure of 304M3-B Fab in complex with H3K4me3 peptide

Summary for 4YHZ

Related4YHP 4YHY
DescriptorFab Heavy Chain, Fab Light Chain, H3K4me3 peptide, ... (6 entities in total)
Functional Keywordsantibody, fab, head-to-head dimerization, h3k4me3, immune system
Biological sourceHomo sapiens
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Total number of polymer chains3
Total molecular weight50149.73
Authors
Hattori, T.,Dementieva, I.S.,Montano, S.P.,Koide, S. (deposition date: 2015-02-27, release date: 2016-02-10, Last modification date: 2017-09-13)
Primary citation
Hattori, T.,Lai, D.,Dementieva, I.S.,Montano, S.P.,Kurosawa, K.,Zheng, Y.,Akin, L.R.,Swist-Rosowska, K.M.,Grzybowski, A.T.,Koide, A.,Krajewski, K.,Strahl, B.D.,Kelleher, N.L.,Ruthenburg, A.J.,Koide, S.
Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation.
Proc.Natl.Acad.Sci.USA, 113:2092-2097, 2016
PubMed: 26862167 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1522691113
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.304 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.217301.1%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 4yhz
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More Biological unit images

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Molmil generated image of 4yhz
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Molmil generated image of 4yhz
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4yhz.pdb1.gz [146.28 KB])
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