8I60

Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr

Summary for 8I60

Entry DOI	10.2210/pdb8i60/pdb
Descriptor	YEATS domain-containing protein 4, ALA-ARG-KCR-SER-ALA-PRO, SULFATE ION, ... (5 entities in total)
Functional Keywords	histone h3 lysine crotonylation, protein binding
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	35746.81
Authors	Konuma, T.,Zhou, M.-M. (deposition date: 2023-01-26, release date: 2023-07-26)
Primary citation	Liu, N.,Konuma, T.,Sharma, R.,Wang, D.,Zhao, N.,Cao, L.,Ju, Y.,Liu, D.,Wang, S.,Bosch, A.,Sun, Y.,Zhang, S.,Ji, D.,Nagatoishi, S.,Suzuki, N.,Kikuchi, M.,Wakamori, M.,Zhao, C.,Ren, C.,Zhou, T.J.,Xu, Y.,Meslamani, J.,Fu, S.,Umehara, T.,Tsumoto, K.,Akashi, S.,Zeng, L.,Roeder, R.G.,Walsh, M.J.,Zhang, Q.,Zhou, M.M. Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin. Mol.Cell, 83:2206-2221.e11, 2023 Cited by PubMed: 37311463 DOI: 10.1016/j.molcel.2023.05.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation