6IQ4

Nucleosome core particle cross-linked with a hetero-binuclear molecule possessing RAPTA and gold(I) 4-(diphenylphosphino)benzoic acid groups.

Summary for 6IQ4

Entry DOI	10.2210/pdb6iq4/pdb
Descriptor	Histone H3.1, MAGNESIUM ION, [Ru(eta(6)-p-cymene)Cl-2(pta), ... (12 entities in total)
Functional Keywords	nucleosome, anticancer, organometallic, cross-link, gold, ruthenium, dna binding protein-dna complex, dna binding protein/dna
Biological source	Homo sapiens (Human) More
Total number of polymer chains	10
Total formula weight	177347.31
Authors	DeFalco, L.,Batchelor, L.K.,Adhireksan, Z.,Dyson, P.J.,Davey, C.A. (deposition date: 2018-11-06, release date: 2019-10-30, Last modification date: 2024-03-27)
Primary citation	Batchelor, L.K.,De Falco, L.,von Erlach, T.,Sharma, D.,Adhireksan, Z.,Roethlisberger, U.,Davey, C.A.,Dyson, P.J. Crosslinking Allosteric Sites on the Nucleosome. Angew.Chem.Int.Ed.Engl., 58:15660-15664, 2019 Cited by PubMed: 31478581 DOI: 10.1002/anie.201906423 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation