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PDB: 175 件
1T83
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CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (ORTHORHOMBIC)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, DIBROMOMERCURY, IGG1, ...
著者Radaev, S, Motyka, S, Fridman, W.-H, Sautes-Fridman, C, Sun, P.D.
登録日2004-05-11
公開日2004-09-28
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The structure of a human type III Fcgamma receptor in complex with Fc
J.Biol.Chem., 276, 2001
7WSO
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Structure of a membrane protein G
分子名称: B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain, Immunoglobulin heavy constant gamma 1
著者Ma, X, Zhu, Y, Chen, Y, Huang, Z.
登録日2022-01-30
公開日2022-08-31
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献Cryo-EM structures of two human B cell receptor isotypes.
Science, 377, 2022
1H3V
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CRYSTAL STRUCTURE OF THE HUMAN IGG1 FC-FRAGMENT,GLYCOFORM (G2F)2,SG P212121
分子名称: IG GAMMA-1 CHAIN C REGION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
著者Krapp, S, Mimura, Y, Jefferis, R, Huber, R, Sondermann, P.
登録日2002-09-19
公開日2003-01-23
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural Analysis of Human Igg-Fc Glycoforms Reveals a Correlation between Glycosylation and Structural Integrity
J.Mol.Biol., 325, 2003
5D6D
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Crystal structure of GASDALIE IgG1 Fc in complex with FcgRIIIa
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region, Low affinity immunoglobulin gamma Fc region receptor III-A, ...
著者Ahmed, A.A, Bjorkman, P.J.
登録日2015-08-12
公開日2016-02-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.13 Å)
主引用文献Structural characterization of GASDALIE Fc bound to the activating Fc receptor Fc gamma RIIIa.
J.Struct.Biol., 194, 2016
3S7G
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Aglycosylated human igg1 fc fragment
分子名称: Ig gamma-1 chain C region
著者Borrok, M.J, Georgiou, G.
登録日2011-05-26
公開日2012-05-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.13 Å)
主引用文献Structural Analysis of an Aglycosylated Fc
To be Published
1E4K
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CRYSTAL STRUCTURE OF SOLUBLE HUMAN IGG1 FC FRAGMENT-FC-GAMMA RECEPTOR III COMPLEX
分子名称: FC FRAGMENT OF HUMAN IGG1, LOW AFFINITY IMMUNOGLOBULIN GAMMA FC RECEPTOR III, alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Sondermann, P, Huber, R, Oosthuizen, V, Jacob, U.
登録日2000-07-07
公開日2000-08-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The 3.2A Crystal Structure of the Human Igg1 Fc Fragment-Fc-Gamma-Riii Complex
Nature, 406, 2000
1FCC
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CRYSTAL STRUCTURE OF THE C2 FRAGMENT OF STREPTOCOCCAL PROTEIN G IN COMPLEX WITH THE FC DOMAIN OF HUMAN IGG
分子名称: IGG1 MO61 FC, STREPTOCOCCAL PROTEIN G (C2 FRAGMENT)
著者Sauer-Eriksson, A.E, Kleywegt, G.J, Uhlen, M, Jones, T.A.
登録日1995-01-17
公開日1995-04-20
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of the C2 fragment of streptococcal protein G in complex with the Fc domain of human IgG.
Structure, 3, 1995
5V4E
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Engineered human IgG Fc domain glyco801 (Fc801)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yan, W, Marshall, N, Zhang, Y.J.
登録日2017-03-09
公開日2017-06-21
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.216 Å)
主引用文献IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions.
Nat. Immunol., 18, 2017
3TYG
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Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with a glycosylated engineered gp120 outer domain with miniV3 (eODmV3)
分子名称: Envelope glycoprotein gp160, PGT128 heavy chain, Ig gamma-1 chain C region, ...
著者Pejchal, R, Huang, P.S, Schief, W.R, Stanfield, R.L, Wilson, I.A.
登録日2011-09-25
公開日2011-10-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.
Science, 334, 2011
5IQ7
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Crystal structure of 10E8-S74W Fab in complex with an HIV-1 gp41 peptide.
分子名称: 10E8-S74W Heavy Chain, 10E8-S74W Light Chain, gp41 MPER peptide
著者Ofek, G, Kwon, Y.D, Caruso, W, Kwong, P.D.
登録日2016-03-10
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2869 Å)
主引用文献Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.
J.Virol., 90, 2016
5K33
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Crystal structure of extracellular domain of HER2 in complex with Fcab STAB19
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ig gamma-1 chain C region, ...
著者Humm, A, Lobner, E, Goritzer, K, Mlynek, G, Obinger, C, Djinovic-Carugo, K.
登録日2016-05-19
公開日2017-04-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.
Structure, 25, 2017
7Q15
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Crystal structure of FcRn and beta-2-microglobulin in complex with IgG1-Fc-MST-HN (efgartigimod)
分子名称: Beta-2-microglobulin, IgG receptor FcRn large subunit p51, IgG1-Fc-MST-HN, ...
著者Pannecoucke, E, Savvides, S.N.
登録日2021-10-18
公開日2022-09-28
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.301 Å)
主引用文献The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.
Nat Commun, 13, 2022
4XNZ
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Crystal structure of broadly and potently neutralizing antibody VRC06B in complex with HIV-1 clade A/E strain 93TH057 gp120
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160,Envelope glycoprotein gp160, ...
著者Zhou, T, Srivatsan, S, Kwong, P.D.
登録日2015-01-16
公開日2015-04-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.389 Å)
主引用文献Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.
Cell, 161, 2015
4DAG
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Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site
分子名称: Fusion glycoprotein F0, Neutralizing Antibody DS7 heavy chain, Neutralizing Antibody DS7 light chain, ...
著者Jardetzky, T.S, Wen, X.
登録日2012-01-12
公開日2012-02-29
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.3904 Å)
主引用文献Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site.
Nat.Struct.Mol.Biol., 19, 2012
4X4M
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Structure of FcgammaRI in complex with Fc reveals the importance of glycan recognition for high affinity IgG binding
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Lu, J, Sun, P.D.
登録日2014-12-03
公開日2015-04-08
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.485 Å)
主引用文献Structure of Fc gamma RI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding.
Proc.Natl.Acad.Sci.USA, 112, 2015
1T89
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CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (HEXAGONAL)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Low affinity immunoglobulin gamma Fc region receptor III-B, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Radaev, S, Motyka, S, Fridman, W.-H, Sautes-Fridman, C, Sun, P.D.
登録日2004-05-11
公開日2004-09-14
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献The structure of a human type III Fcgamma receptor in complex with Fc
J.Biol.Chem., 276, 2001
4N0U
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Ternary complex between Neonatal Fc receptor, serum albumin and Fc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Ig gamma-1 chain C region, ...
著者Oganesyan, V, Wu, H, Dall'Acqua, W.F.
登録日2013-10-02
公開日2014-02-05
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms.
J.Biol.Chem., 289, 2014
3RY6
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Complex of fcgammariia (CD32) and the FC of human IGG1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ig gamma-1 chain C region, ...
著者Ramsland, P.A, Farrugia, W, Scott, A.M, Hogarth, P.M.
登録日2011-05-11
公開日2011-08-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structural Basis for Fc{gamma}RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes.
J.Immunol., 187, 2011
1H3Y
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Crystal structure of a human IgG1 Fc-fragment,high salt condition
分子名称: IG GAMMA-1 CHAIN C REGION, alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
著者Krapp, S, Mimura, Y, Jefferis, R, Huber, R, Sondermann, P.
登録日2002-09-19
公開日2003-01-23
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (4.1 Å)
主引用文献Structural Analysis of Human Igg-Fc Glycoforms Reveals a Correlation between Glycosylation and Structural Integrity.
J.Mol.Biol., 325, 2003
6DE7
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Crystal Structure at 4.3 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Interdomain Stabilization 113C-429GCG in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 heavy chain, ...
著者Gorman, J, Kwong, P.D.
登録日2018-05-11
公開日2018-06-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (4.123 Å)
主引用文献Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer.
Cell Host Microbe, 23, 2018
5K8D
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Crystal structure of rFVIIIFc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (II) ION, ...
著者Leksa, N, Quan, C.
登録日2016-05-29
公開日2017-06-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (4.19 Å)
主引用文献The structural basis for the functional comparability of factor VIII and the long-acting variant recombinant factor VIII Fc fusion protein.
J. Thromb. Haemost., 15, 2017
5KWG
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Crystal structure of extracellular domain of HER2 in complex with Fcab H10-03-6
分子名称: Ig gamma-1 chain C region, Receptor tyrosine-protein kinase erbB-2
著者Humm, A, Lobner, E, Goritzer, K, Mlynek, G, Obinger, C, Djinovic-Carugo, K.
登録日2016-07-18
公開日2017-04-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (4.3 Å)
主引用文献Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.
Structure, 25, 2017
5C7K
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Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab 8ANC195 heavy chain, ...
著者Kong, L, Stanfield, R.L, Wilson, I.A.
登録日2015-06-24
公開日2015-10-07
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (4.6019 Å)
主引用文献Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.
Acta Crystallogr.,Sect.D, 71, 2015
2GJ7
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Crystal Structure of a gE-gI/Fc complex
分子名称: Glycoprotein E, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
著者Sprague, E.R, Wang, C, Baker, D, Bjorkman, P.J.
登録日2006-03-30
公開日2006-05-30
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (5 Å)
主引用文献Crystal Structure of the HSV-1 Fc Receptor Bound to Fc Reveals a Mechanism for Antibody Bipolar Bridging.
Plos Biol., 4, 2006
2RCJ
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Solution structure of human Immunoglobulin M
分子名称: IgA1 heavy chain, IgA1 light chain, J chain
著者Perkins, S.J, Nealis, A.S, Sutton, B.J, Feinstein, A.
登録日2007-09-20
公開日2008-01-22
最終更新日2024-02-21
実験手法SOLUTION SCATTERING
主引用文献Solution structure of human and mouse immunoglobulin M by synchrotron X-ray scattering and molecular graphics modelling. A possible mechanism for complement activation.
J.Mol.Biol., 221, 1991

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