5K8D

Crystal structure of rFVIIIFc

Summary for 5K8D

• Entry DOI: 10.2210/pdb5k8d/pdb
• Descriptor: Coagulation factor VIII, Coagulation factor VIII,Ig gamma-1 chain C region, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: coagulation factor, factor viii, human igg1 fc domain, hemophilia a, blood clotting
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 186530.06

Authors

Leksa, N.,Quan, C. (deposition date: 2016-05-29, release date: 2017-06-14, Last modification date: 2023-09-27)

• Primary citation: Leksa, N.C.,Chiu, P.L.,Bou-Assaf, G.M.,Quan, C.,Liu, Z.,Goodman, A.B.,Chambers, M.G.,Tsutakawa, S.E.,Hammel, M.,Peters, R.T.,Walz, T.,Kulman, J.D.; The structural basis for the functional comparability of factor VIII and the long-acting variant recombinant factor VIII Fc fusion protein.; J. Thromb. Haemost., 15:1167-1179, 2017; PubMed: 28397397; DOI: 10.1111/jth.13700

Experimental method

X-RAY DIFFRACTION (4.19 Å)