5K8D
Crystal structure of rFVIIIFc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Coagulation factor VIII | polymer | 740 | 84775.8 | 1 | UniProt (P00451) Pfam (PF07732) | Homo sapiens (Human) | Antihemophilic factor,AHF,Procoagulant component |
| 2 | B (B) | Coagulation factor VIII,Ig gamma-1 chain C region | polymer | 865 | 99098.7 | 1 | UniProt (P00451) UniProt (P01857) Pfam (PF07731) Pfam (PF00754) Pfam (PF07654) | Homo sapiens (Human) | Antihemophilic factor,AHF,Procoagulant component |
| 3 | C (C) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 4 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E (E) | alpha-D-mannopyranose-(1-2)-beta-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G71177VF) | |||
| 6 | F, G, H (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 7 | I, J (A, B) | COPPER (II) ION | non-polymer | 63.5 | 2 | Chemie (CU) |
Sequence modifications
B: 1694 - 2331 (UniProt: P00451)
B: 2333 - 2558 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Tyr 2332 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 183874.5 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 2408.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 247.3 | |
| All* | Total formula weight | 186530.1 |
