5IQ7

Crystal structure of 10E8-S74W Fab in complex with an HIV-1 gp41 peptide.

Summary for 5IQ7

• Entry DOI: 10.2210/pdb5iq7/pdb
• Descriptor: 10E8-S74W Heavy Chain, 10E8-S74W Light Chain, gp41 MPER peptide (3 entities in total)
• Functional Keywords: immunoglobulin, mper, antibody, immune system
• Biological source: Homo sapiens; More
• Cellular location: Secreted : P01857
• Total number of polymer chains: 3
• Total formula weight: 52511.61

Authors

Ofek, G.,Kwon, Y.D.,Caruso, W.,Kwong, P.D. (deposition date: 2016-03-10, release date: 2016-04-20, Last modification date: 2023-09-27)

• Primary citation: Kwon, Y.D.,Georgiev, I.S.,Ofek, G.,Zhang, B.,Asokan, M.,Bailer, R.T.,Bao, A.,Caruso, W.,Chen, X.,Choe, M.,Druz, A.,Ko, S.Y.,Louder, M.K.,McKee, K.,O'Dell, S.,Pegu, A.,Rudicell, R.S.,Shi, W.,Wang, K.,Yang, Y.,Alger, M.,Bender, M.F.,Carlton, K.,Cooper, J.W.,Blinn, J.,Eudailey, J.,Lloyd, K.,Parks, R.,Alam, S.M.,Haynes, B.F.,Padte, N.N.,Yu, J.,Ho, D.D.,Huang, J.,Connors, M.,Schwartz, R.M.,Mascola, J.R.,Kwong, P.D.; Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.; J.Virol., 90:5899-5914, 2016; PubMed: 27053554; DOI: 10.1128/JVI.03246-15

Experimental method

X-RAY DIFFRACTION (3.2869 Å)