7Q15
Crystal structure of FcRn and beta-2-microglobulin in complex with IgG1-Fc-MST-HN (efgartigimod)
Summary for 7Q15
| Entry DOI | 10.2210/pdb7q15/pdb |
| Descriptor | IgG receptor FcRn large subunit p51, Beta-2-microglobulin, IgG1-Fc-MST-HN, ... (5 entities in total) |
| Functional Keywords | neonatal fc receptor fcrn, fcrn, fc, igg1-fc-mst-hn, efgartigimod, argx-113, fcrn-binding protein, immune system |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 6 |
| Total formula weight | 155950.13 |
| Authors | Pannecoucke, E.,Savvides, S.N. (deposition date: 2021-10-18, release date: 2022-09-28, Last modification date: 2024-02-07) |
| Primary citation | Brinkhaus, M.,Pannecoucke, E.,van der Kooi, E.J.,Bentlage, A.E.H.,Derksen, N.I.L.,Andries, J.,Balbino, B.,Sips, M.,Ulrichts, P.,Verheesen, P.,de Haard, H.,Rispens, T.,Savvides, S.N.,Vidarsson, G. The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement. Nat Commun, 13:6073-6073, 2022 Cited by PubMed: 36241613DOI: 10.1038/s41467-022-33764-1 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.301 Å) |
Structure validation
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