7Q15

Crystal structure of FcRn and beta-2-microglobulin in complex with IgG1-Fc-MST-HN (efgartigimod)

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0006955	biological_process	immune response
B	0042612	cellular_component	MHC class I protein complex
D	0006955	biological_process	immune response
D	0042612	cellular_component	MHC class I protein complex

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YCCIVQH

Chain	Residue	Details
A	TYR250-HIS256
B	TYR78-HIS84
E	PHE423-HIS429

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:11406581, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19358553, ECO:0000269|PubMed:20357243

Chain	Residue	Details
E	ASN297
F	ASN297

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443

Chain	Residue	Details
B	ILE1
D	ILE1

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site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443

Chain	Residue	Details
B	LYS19
D	LYS58
D	LYS91
D	LYS94
B	LYS41
B	LYS48
B	LYS58
B	LYS91
B	LYS94
D	LYS19
D	LYS41
D	LYS48

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