7Q15
Crystal structure of FcRn and beta-2-microglobulin in complex with IgG1-Fc-MST-HN (efgartigimod)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | IgG receptor FcRn large subunit p51 | polymer | 338 | 37225.8 | 2 | UniProt (P55899) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (human) | FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor |
| 2 | B, D (B, D) | Beta-2-microglobulin | polymer | 119 | 13732.5 | 2 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | E, F (E, F) | IgG1-Fc-MST-HN | polymer | 225 | 25492.8 | 2 | Pfam (PF07654) UniProt (by SIFTS) (P01857) | Homo sapiens (Human) | |
| 4 | G (G) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 1 | In PDB GlyTouCan (G27919IH) | |||
| 5 | H (H) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1422.3 | 1 | In PDB GlyTouCan (G12398HZ) |
Sequence modifications
A, C: -22 - 274 (UniProt: P55899)
| PDB | External Database | Details |
|---|---|---|
| Gly 275 | - | expression tag |
| Thr 276 | - | expression tag |
| Ser 277 | - | expression tag |
| Gly 278 | - | expression tag |
| Leu 279 | - | expression tag |
| Val 280 | - | expression tag |
| Pro 281 | - | expression tag |
| Arg 282 | - | expression tag |
| Gly 283 | - | expression tag |
| Ser 284 | - | expression tag |
| Gly 285 | - | expression tag |
| Gly 286 | - | expression tag |
| Ser 287 | - | expression tag |
| Gly 288 | - | expression tag |
| Gly 289 | - | expression tag |
| Ser 290 | - | expression tag |
| Gly 291 | - | expression tag |
| Leu 292 | - | expression tag |
| Asn 293 | - | expression tag |
| Asp 294 | - | expression tag |
| Ile 295 | - | expression tag |
| Phe 296 | - | expression tag |
| Glu 297 | - | expression tag |
| Ala 298 | - | expression tag |
| Gln 299 | - | expression tag |
| Lys 300 | - | expression tag |
| Ile 301 | - | expression tag |
| Glu 302 | - | expression tag |
| Trp 303 | - | expression tag |
| His 304 | - | expression tag |
| Glu 305 | - | expression tag |
| Gly 306 | - | expression tag |
| Arg 307 | - | expression tag |
| Thr 308 | - | expression tag |
| Lys 309 | - | expression tag |
| His 310 | - | expression tag |
| His 311 | - | expression tag |
| His 312 | - | expression tag |
| His 313 | - | expression tag |
| His 314 | - | expression tag |
| His 315 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 152902.3 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3047.8 | |
| All* | Total formula weight | 155950.1 |
