7Q15
Crystal structure of FcRn and beta-2-microglobulin in complex with IgG1-Fc-MST-HN (efgartigimod)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | IgG receptor FcRn large subunit p51 | polymer | 338 | 37225.8 | 2 | UniProt (P55899) Pfam (PF00129) Pfam (PF07654) In PDB | Homo sapiens (human) | FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor |
2 | B, D | Beta-2-microglobulin | polymer | 119 | 13732.5 | 2 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (human) | |
3 | E, F | IgG1-Fc-MST-HN | polymer | 225 | 25492.8 | 2 | Pfam (PF07654) UniProt (by SIFTS) (P01857) In PDB | Homo sapiens (Human) | |
4 | G | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 1 | In PDB GlyTouCan (G27919IH) | |||
5 | H | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1422.3 | 1 | In PDB GlyTouCan (G12398HZ) |
Sequence modifications
A, C: -22 - 274 (UniProt: P55899)
PDB | External Database | Details |
---|---|---|
Gly 275 | - | expression tag |
Thr 276 | - | expression tag |
Ser 277 | - | expression tag |
Gly 278 | - | expression tag |
Leu 279 | - | expression tag |
Val 280 | - | expression tag |
Pro 281 | - | expression tag |
Arg 282 | - | expression tag |
Gly 283 | - | expression tag |
Ser 284 | - | expression tag |
Gly 285 | - | expression tag |
Gly 286 | - | expression tag |
Ser 287 | - | expression tag |
Gly 288 | - | expression tag |
Gly 289 | - | expression tag |
Ser 290 | - | expression tag |
Gly 291 | - | expression tag |
Leu 292 | - | expression tag |
Asn 293 | - | expression tag |
Asp 294 | - | expression tag |
Ile 295 | - | expression tag |
Phe 296 | - | expression tag |
Glu 297 | - | expression tag |
Ala 298 | - | expression tag |
Gln 299 | - | expression tag |
Lys 300 | - | expression tag |
Ile 301 | - | expression tag |
Glu 302 | - | expression tag |
Trp 303 | - | expression tag |
His 304 | - | expression tag |
Glu 305 | - | expression tag |
Gly 306 | - | expression tag |
Arg 307 | - | expression tag |
Thr 308 | - | expression tag |
Lys 309 | - | expression tag |
His 310 | - | expression tag |
His 311 | - | expression tag |
His 312 | - | expression tag |
His 313 | - | expression tag |
His 314 | - | expression tag |
His 315 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 152902.3 | |
Branched | Number of molecules | 2 |
Total formula weight | 3047.8 | |
All* | Total formula weight | 155950.1 |