3QF2
| Crystal structure of NALP3 PYD | Descriptor: | NACHT, LRR and PYD domains-containing protein 3 | Authors: | Park, H.H, Bae, J.Y. | Deposit date: | 2011-01-21 | Release date: | 2011-08-31 | Last modified: | 2011-11-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure of NALP3 Protein Pyrin Domain (PYD) and Its Implications in Inflammasome Assembly J.Biol.Chem., 286, 2011
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1UCP
| NMR structure of the PYRIN domain of human ASC | Descriptor: | Apoptosis-associated speck-like protein containing a CARD | Authors: | Liepinsh, E, Barbals, R, Dahl, E, Sharipo, A, Staub, E, Otting, G. | Deposit date: | 2003-04-16 | Release date: | 2003-11-04 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition J.Mol.Biol., 332, 2003
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6Z2G
| Crystal structure of human NLRP9 PYD | Descriptor: | NACHT, LRR and PYD domains-containing protein 9 | Authors: | Marleaux, M, Anand, K, Geyer, M. | Deposit date: | 2020-05-15 | Release date: | 2020-06-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly. Febs Lett., 594, 2020
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3J63
| Unified assembly mechanism of ASC-dependent inflammasomes | Descriptor: | Apoptosis-associated speck-like protein containing a CARD | Authors: | Lu, A, Magupalli, V.G, Ruan, J, Yin, Q, Atianand, M.K, Vos, M, Schroder, G.F, Fitzgerald, K.A, Wu, H, Egelman, E.H. | Deposit date: | 2013-12-05 | Release date: | 2014-03-26 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes. Cell(Cambridge,Mass.), 156, 2014
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8ERT
| NLRP3 PYD filament | Descriptor: | NACHT, LRR and PYD domains-containing protein 3 | Authors: | Wu, H, Xiao, L. | Deposit date: | 2022-10-12 | Release date: | 2022-12-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of the active NLRP3 inflammasome disc. Nature, 613, 2023
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7K3R
| Cryo-EM structure of AIM2-PYD filament | Descriptor: | Interferon-inducible protein AIM2 | Authors: | Zheng, W, Matyszewski, M, Sohn, J, Egelman, E.H. | Deposit date: | 2020-09-12 | Release date: | 2021-05-26 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome. Nat Commun, 12, 2021
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4EWI
| Crystal structure of the NLRP4 Pyrin domain | Descriptor: | CHLORIDE ION, NACHT, LRR and PYD domains-containing protein 4, ... | Authors: | Eibl, C, Hessenberger, M, Puehringer, S, Page, R, Diederichs, K, Peti, W. | Deposit date: | 2012-04-27 | Release date: | 2012-09-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural and Functional Analysis of the NLRP4 Pyrin Domain. Biochemistry, 51, 2012
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2YU0
| Solution structures of the PAAD_DAPIN domain of mus musculus interferon-activatable protein 205 | Descriptor: | Interferon-activable protein 205 | Authors: | Sato, M, Tochio, N, Koshiba, S, Watanabe, M, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-05 | Release date: | 2008-02-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structures of the PAAD_DAPIN domain of mus musculus interferon-activatable protein 205 To be Published
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4QOB
| Crystal structure of cPOP1 | Descriptor: | Pyrin domain-containing protein 1 | Authors: | Park, H.H. | Deposit date: | 2014-06-19 | Release date: | 2015-11-04 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of cPOP1 To be Published
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7BSO
| Crystal structure of the human NLRP9 pyrin domain | Descriptor: | NACHT, LRR and PYD domains-containing protein 9 | Authors: | Park, H.H, Ha, H.J. | Deposit date: | 2020-03-31 | Release date: | 2021-02-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Crystal structure of the human NLRP9 pyrin domain reveals a bent N-terminal loop that may regulate inflammasome assembly. Febs Lett., 594, 2020
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2DBG
| Solution structure of the Pyrin (PAAD-DAPIN) domain in human Myeloid cell nuclear differentiation antigen | Descriptor: | Myeloid cell nuclear differentiation antigen | Authors: | Saito, K, Inoue, M, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-12-15 | Release date: | 2006-06-15 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the Pyrin (PAAD-DAPIN) domain in human Myeloid cell nuclear differentiation antigen To be Published
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2DO9
| Solution structure of the Pyrin/PAAD-DAPIN domain in mouse NALP10 (NACHT, leucine rich repeat and PYD containing 10) | Descriptor: | NACHT-, LRR- and PYD-containing protein 10 | Authors: | Saito, K, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-04-28 | Release date: | 2006-10-28 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the Pyrin/PAAD-DAPIN domain in mouse NALP10 (NACHT, leucine rich repeat and PYD containing 10) To be Published
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7PZD
| Cryo-EM structure of the NLRP3 PYD filament | Descriptor: | NACHT, LRR and PYD domains-containing protein 3 | Authors: | Hochheiser, I.V, Hagelueken, G, Behrmann, H, Behrmann, E, Geyer, M. | Deposit date: | 2021-10-12 | Release date: | 2022-04-20 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation. Sci Adv, 8, 2022
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7E5B
| Crystal structure of ASC PYD Domain and Rb-B7 | Descriptor: | Apoptosis-associated speck-like protein containing a CARD, GLYCEROL, Repebody (Rb-B7) | Authors: | Cho, H.S, Cha, J.S. | Deposit date: | 2021-02-18 | Release date: | 2022-03-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space. Cell Death Discov, 9, 2023
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6NCV
| Cryo-EM structure of NLRP6 PYD filament | Descriptor: | NACHT, LRR and PYD domains-containing protein 6 | Authors: | Shen, C, Fu, T.M, Wu, H. | Deposit date: | 2018-12-12 | Release date: | 2019-01-23 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular mechanism for NLRP6 inflammasome assembly and activation. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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4N1J
| Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions | Descriptor: | GLYCEROL, NACHT, LRR and PYD domains-containing protein 14 | Authors: | Eibl, C, Hessenberger, M, Wenger, J, Brandstetter, H. | Deposit date: | 2013-10-04 | Release date: | 2014-07-16 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions. Acta Crystallogr.,Sect.D, 70, 2014
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2KM6
| NMR structure of the NLRP7 Pyrin domain | Descriptor: | NACHT, LRR and PYD domains-containing protein 7 | Authors: | Pinheiro, A, Proell, M, Schwarzenbacher, R, Peti, W. | Deposit date: | 2009-07-21 | Release date: | 2010-06-09 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Three-dimensional structure of the NLRP7 pyrin domain: insight into pyrin-pyrin-mediated effector domain signaling in innate immunity. J.Biol.Chem., 285, 2010
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2HM2
| Solution structure of ASC2 | Descriptor: | Pyrin-only protein 1 | Authors: | Natarajan, A, Ghose, R, Hill, J.M. | Deposit date: | 2006-07-11 | Release date: | 2006-07-25 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure and dynamics of ASC2, a pyrin domain-only protein that regulates inflammatory signaling J.Biol.Chem., 281, 2006
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4N1K
| Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions | Descriptor: | NACHT, LRR and PYD domains-containing protein 14 | Authors: | Eibl, C, Hessenberger, M, Wenger, J, Brandstetter, H. | Deposit date: | 2013-10-04 | Release date: | 2014-07-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions. Acta Crystallogr.,Sect.D, 70, 2014
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4O7Q
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4N1L
| Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions | Descriptor: | NACHT, LRR and PYD domains-containing protein 14 | Authors: | Eibl, C, Hessenberger, M, Wenger, J, Brandstetter, H. | Deposit date: | 2013-10-04 | Release date: | 2014-07-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.986 Å) | Cite: | Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions. Acta Crystallogr.,Sect.D, 70, 2014
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2L6A
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2M5V
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2MPC
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2N1F
| Structure and assembly of the mouse ASC filament by combined NMR spectroscopy and cryo-electron microscopy | Descriptor: | Apoptosis-associated speck-like protein | Authors: | Sborgi, L, Ravotti, F, Dandey, V, Dick, M, Mazur, A, Reckel, S, Chami, M, Scherer, S, Bockmann, A, Egelman, E, Stahlberg, H, Broz, P, Meier, B, Hiller, S. | Deposit date: | 2015-04-01 | Release date: | 2015-10-14 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4 Å), SOLID-STATE NMR | Cite: | Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy. Proc.Natl.Acad.Sci.USA, 112, 2015
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