6NCV

Cryo-EM structure of NLRP6 PYD filament

Summary for 6NCV

• Entry DOI: 10.2210/pdb6ncv/pdb
• EMDB information: 0438
• Descriptor: NACHT, LRR and PYD domains-containing protein 6 (1 entity in total)
• Functional Keywords: death domain fold, helical assembly, inflammasome, signaling protein, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 21
• Total formula weight: 250563.16

Authors

Shen, C.,Fu, T.M.,Wu, H. (deposition date: 2018-12-12, release date: 2019-01-23, Last modification date: 2024-03-20)

• Primary citation: Shen, C.,Lu, A.,Xie, W.J.,Ruan, J.,Negro, R.,Egelman, E.H.,Fu, T.M.,Wu, H.; Molecular mechanism for NLRP6 inflammasome assembly and activation.; Proc. Natl. Acad. Sci. U.S.A., 116:2052-2057, 2019; PubMed: 30674671; DOI: 10.1073/pnas.1817221116

Experimental method

ELECTRON MICROSCOPY (3.7 Å)