7PZD
Cryo-EM structure of the NLRP3 PYD filament
Summary for 7PZD
| Entry DOI | 10.2210/pdb7pzd/pdb |
| EMDB information | 13727 |
| Descriptor | NACHT, LRR and PYD domains-containing protein 3 (1 entity in total) |
| Functional Keywords | nlrp3, pyrin domain, filament, immune system |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 18 |
| Total formula weight | 224752.37 |
| Authors | Hochheiser, I.V.,Hagelueken, G.,Behrmann, H.,Behrmann, E.,Geyer, M. (deposition date: 2021-10-12, release date: 2022-04-20, Last modification date: 2022-05-25) |
| Primary citation | Hochheiser, I.V.,Behrmann, H.,Hagelueken, G.,Rodriguez-Alcazar, J.F.,Kopp, A.,Latz, E.,Behrmann, E.,Geyer, M. Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation. Sci Adv, 8:eabn7583-eabn7583, 2022 Cited by PubMed: 35559676DOI: 10.1126/sciadv.abn7583 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
Download full validation report
