7M40
| Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4) | Descriptor: | Histone-binding protein RBBP4, N~3~-{4-[3-(dimethylamino)pyrrolidin-1-yl]-6,7-dimethoxyquinazolin-2-yl}-N~1~,N~1~-dimethylpropane-1,3-diamine | Authors: | Perveen, S, Dong, A, Tempel, W, Zepeda-Velazquez, C, Abbey, M, McLeod, D, Marcellus, R, Mohammed, M, Ensan, D, Panagopoulos, D, Trush, V, Gibson, E, Brown, P.J, Arrowsmith, C.H, Schapira, M, Al-awar, R, Vedadi, M, Structural Genomics Consortium (SGC) | Deposit date: | 2021-03-19 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4) To Be Published
|
|
8CGK
| Lincomycin and Avilamycin bound to the 50S subunit | Descriptor: | (2R,3S,4R,6S)-4-hydroxy-6-{[(2R,3aR,4R,4'R,5'S,6S,6'R,7aR)-4'-hydroxy-6-{[(2S,3R,4R,5S,6R)-3-hydroxy-2-{[(2R,3S,4S,5S,6S)-4-hydroxy-6-({(2R,3aS,3a'R,6S,6'R,7R,7'R,7aR,7a'R)-7'-hydroxy-7'-[(1S)-1-hydroxyethyl]-6'-methyl-7-[(2-methylpropanoyl)oxy]octahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl}oxy)-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl]oxy}-4,6',7a-trimethyloctahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-5'-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate (non-preferred name), 23S rRNA, 50S ribosomal protein L15, ... | Authors: | Paternoga, H, Crowe-McAuliffe, C, Beckert, B, Wilson, D.N. | Deposit date: | 2023-02-05 | Release date: | 2023-07-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (1.64 Å) | Cite: | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
|
|
8CGD
| Clindamycin bound to the 50S subunit | Descriptor: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | Authors: | Paternoga, H, Koller, T.O, Beckert, B, Wilson, D.N. | Deposit date: | 2023-02-03 | Release date: | 2023-07-26 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (1.98 Å) | Cite: | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
|
|
8CEU
| Retapamulin and Capreomycin bound to the 50S subunit | Descriptor: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | Authors: | Paternoga, H, Beckert, B, Wilson, D.N. | Deposit date: | 2023-02-02 | Release date: | 2023-07-26 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (1.83 Å) | Cite: | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
|
|
6OEV
| Structure of human Patched1 in complex with native Sonic Hedgehog | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1, ... | Authors: | Qi, X, Li, X. | Deposit date: | 2019-03-27 | Release date: | 2019-04-17 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of human Patched and its complex with native palmitoylated sonic hedgehog. Nature, 560, 2018
|
|
8CAM
| Evernimicin bound to the 50S subunit | Descriptor: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | Authors: | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | Deposit date: | 2023-01-24 | Release date: | 2023-07-26 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (1.86 Å) | Cite: | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
|
|
8QO9
| Cryo-EM structure of a human spliceosomal B complex protomer | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. | Deposit date: | 2023-09-28 | Release date: | 2024-01-24 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (5.29 Å) | Cite: | Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. Embo J., 43, 2024
|
|
6OEU
| Structure of human Patched1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1 | Authors: | Qi, X, Li, X, Wang, J. | Deposit date: | 2019-03-27 | Release date: | 2019-04-10 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of human Patched and its complex with native palmitoylated sonic hedgehog. Nature, 560, 2018
|
|
8C91
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Lauer, S, Nikolay, R, Qin, B. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.19 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
|
|
8C8X
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Lauer, S, Nikolay, R, Qin, B. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
|
|
8C8Y
| Cryo-EM captures early ribosome assembly in action | Descriptor: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Lauer, S, Nikolay, R, Qin, B. | Deposit date: | 2023-01-21 | Release date: | 2023-04-05 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Cryo-EM captures early ribosome assembly in action. Nat Commun, 14, 2023
|
|
8I2K
| |
8AS5
| |
5L4G
| The human 26S proteasome at 3.9 A | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | Authors: | Schweitzer, A, Aufderheide, A, Rudack, T, Beck, F. | Deposit date: | 2016-05-25 | Release date: | 2016-09-07 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure of the human 26S proteasome at a resolution of 3.9 angstrom. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
7D6Z
| Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase and trigger factor | Descriptor: | 16S ribosomal rRNA, 23S ribosomal rRNA, 30S ribosomal protein S10, ... | Authors: | Akbar, S, Bhakta, S, Sengupta, J. | Deposit date: | 2020-10-02 | Release date: | 2021-04-07 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into the interplay of protein biogenesis factors with the 70S ribosome. Structure, 29, 2021
|
|
6U5K
| CryoEM Structure of Pyocin R2 - postcontracted - baseplate | Descriptor: | Glue PA0627, Sheath Initiator PA0617, Sheath PA0622, ... | Authors: | Ge, P, Avaylon, J, Scholl, D, Shneider, M.M, Browning, C, Buth, S.A, Plattner, M, Ding, K, Leiman, P.G, Miller, J.F, Zhou, Z.H. | Deposit date: | 2019-08-27 | Release date: | 2020-04-15 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Action of a minimal contractile bactericidal nanomachine. Nature, 580, 2020
|
|
3L8S
| Human p38 MAP Kinase in Complex with CP-547632 | Descriptor: | 3-[(4-bromo-2,6-difluorobenzyl)oxy]-5-{[(4-pyrrolidin-1-ylbutyl)carbamoyl]amino}isothiazole-4-carboxamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | Authors: | Gruetter, C, Simard, J.R, Rauh, D. | Deposit date: | 2010-01-03 | Release date: | 2010-03-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations. J.Am.Chem.Soc., 132, 2010
|
|
6UMX
| Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015 | Descriptor: | GL29H4-16 Fab Heavy Chain,GL29H4-16 Fab Heavy Chain, GL29H4-16 Fab Light Chain,GL29H4-16 Fab Light Chain, GLYCEROL, ... | Authors: | Dagbay, K.B, Treece, E, Streich Jr, F.C, Jackson, J.W, Faucette, R.R, Nikiforov, A, Lin, S.C, Bostion, C.J, Nicholls, S.B, Capili, A.D, Carven, G.J. | Deposit date: | 2019-10-10 | Release date: | 2020-02-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015. J.Biol.Chem., 295, 2020
|
|
6U1N
| GPCR-Beta arrestin structure in lipid bilayer | Descriptor: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, Beta-arrestin-1, Fab30 heavy chain, ... | Authors: | Staus, D.P, Hu, H, Robertson, M.J, Kleinhenz, A.L.W, Wingler, L.M, Capel, W.D, Latorraca, N.R, Lefkowitz, R.J, Skiniotis, G. | Deposit date: | 2019-08-16 | Release date: | 2020-02-26 | Last modified: | 2020-03-25 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of the M2 muscarinic receptor-beta-arrestin complex in a lipid nanodisc. Nature, 579, 2020
|
|
4MLO
| 1.65A resolution structure of ToxT from Vibrio cholerae (P21 Form) | Descriptor: | CHLORIDE ION, PALMITOLEIC ACID, TCP pilus virulence regulatory protein | Authors: | Lovell, S, Wehmeyer, G, Battaile, K.P, Li, J, Egan, S. | Deposit date: | 2013-09-06 | Release date: | 2016-04-20 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | 1.65 angstrom resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae. Acta Crystallogr F Struct Biol Commun, 72, 2016
|
|
3LHJ
| Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor. | Descriptor: | Mitogen-activated protein kinase 14, N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-4-methylbenzamide | Authors: | Mohr, C, Jordan, S. | Deposit date: | 2010-01-22 | Release date: | 2010-04-14 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.31 Å) | Cite: | Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase. J.Med.Chem., 53, 2010
|
|
3L8X
| P38 alpha kinase complexed with a pyrazolo-pyrimidine based inhibitor | Descriptor: | Mitogen-activated protein kinase 14, N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Authors: | Sack, J.S. | Deposit date: | 2010-01-04 | Release date: | 2010-03-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Pyrazolo-Pyrimidines: A Novel Heterocyclic Scaffold for Potent and Selective P38 Alpha Inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
|
|
6UMZ
| |
6U5F
| CryoEM Structure of Pyocin R2 - precontracted - collar | Descriptor: | Collar PA0615, Sheath PA0622, Tube PA0623 | Authors: | Ge, P, Avaylon, J, Scholl, D, Shneider, M.M, Browning, C, Buth, S.A, Plattner, M, Ding, K, Leiman, P.G, Miller, J.F, Zhou, Z.H. | Deposit date: | 2019-08-27 | Release date: | 2020-04-15 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Action of a minimal contractile bactericidal nanomachine. Nature, 580, 2020
|
|
3LFC
| Human p38 MAP Kinase in Complex with RL99 | Descriptor: | (4-{5-[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}carbamoyl)amino]-3-tert-butyl-1H-pyrazol-1-yl}phenyl)acetic acid, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | Authors: | Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. | Deposit date: | 2010-01-16 | Release date: | 2011-04-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha To be Published
|
|