7M40

Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)

Summary for 7M40

• Entry DOI: 10.2210/pdb7m40/pdb
• Descriptor: Histone-binding protein RBBP4, N~3~-{4-[3-(dimethylamino)pyrrolidin-1-yl]-6,7-dimethoxyquinazolin-2-yl}-N~1~,N~1~-dimethylpropane-1,3-diamine (3 entities in total)
• Functional Keywords: rbbp4, structural genomics, structural genomics consortium, sgc, gene regulation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 100624.84

Authors

Perveen, S.,Dong, A.,Tempel, W.,Zepeda-Velazquez, C.,Abbey, M.,McLeod, D.,Marcellus, R.,Mohammed, M.,Ensan, D.,Panagopoulos, D.,Trush, V.,Gibson, E.,Brown, P.J.,Arrowsmith, C.H.,Schapira, M.,Al-awar, R.,Vedadi, M.,Structural Genomics Consortium (SGC) (deposition date: 2021-03-19, release date: 2021-05-12, Last modification date: 2023-10-18)

• Primary citation: Perveen, S.,Zepeda-Velazquez, C.,Abbey, M.,McLeod, D.,Marcellus, R.,Mohammed, M.,Ensan, D.,Panagopoulos, D.,Trush, V.,Gibson, E.,Tempel, W.,Brown, P.J.,Arrowsmith, C.H.,Schapira, M.,Al-awar, R.,Vedadi, M.,Structural Genomics Consortium (SGC); Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4); To Be Published,

Experimental method

X-RAY DIFFRACTION (1.88 Å)