3LHJ
Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor.
Summary for 3LHJ
Entry DOI | 10.2210/pdb3lhj/pdb |
Related | 1YQJ 3DS6 3DT1 3GFE 3ITZ |
Descriptor | Mitogen-activated protein kinase 14, N-cyclopropyl-3-[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-4-methylbenzamide (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase, transferase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42433.38 |
Authors | Mohr, C.,Jordan, S. (deposition date: 2010-01-22, release date: 2010-04-14, Last modification date: 2024-02-21) |
Primary citation | Pettus, L.H.,Wurz, R.P.,Xu, S.,Herberich, B.,Henkle, B.,Liu, Q.,McBride, H.J.,Mu, S.,Plant, M.H.,Saris, C.J.,Sherman, L.,Wong, L.M.,Chmait, S.,Lee, M.R.,Mohr, C.,Hsieh, F.,Tasker, A.S. Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase. J.Med.Chem., 53:2973-2985, 2010 Cited by PubMed: 20218619DOI: 10.1021/jm100095x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.31 Å) |
Structure validation
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