PDB: 37224 resultsInfo pagesStatus searchChemie searchBIRD

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7Q33	Solution structure of RBM39 RRM2 bound to 5'-AGCUUUG-3 Descriptor: RNA (5'-R(*AP*GP*CP*UP*UP*UP*G)-3'), RNA-binding protein 39 Authors: Campagne, S, Allain, F.H. Deposit date: 2021-10-26 Release date: 2023-02-08 Last modified: 2023-09-20 Method: SOLUTION NMR Cite: Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39. Nat Commun, 14, 2023
5FPN	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 3,5-dimethyl-1H-pyrazole-4-carboxylic acid (AT9084) in an alternate binding site. Descriptor: 3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID, HEAT SHOCK-RELATED 70 KDA PROTEIN 2 Authors: Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. Deposit date: 2015-12-02 Release date: 2015-12-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
7JN0	Sheep Connexin-46 at 2.5 angstroms resolution, Lipid Class 2 Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Gap junction alpha-3 protein Authors: Flores, J.A, Haddad, B.G, Dolan, K.A, Myers, J.A, Yoshioka, C.C, Copperman, J, Zuckerman, D.M, Reichow, S.L. Deposit date: 2020-08-03 Release date: 2020-09-09 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 angstrom. Nat Commun, 11, 2020
8CPP	CRYSTAL STRUCTURES OF CYTOCHROME P450-CAM COMPLEXED WITH CAMPHANE, THIOCAMPHOR, AND ADAMANTANE: FACTORS CONTROLLING P450 SUBSTRATE HYDROXYLATION Descriptor: CYTOCHROME P450CAM, PROTOPORPHYRIN IX CONTAINING FE, THIOCAMPHOR Authors: Raag, R, Poulos, T.L. Deposit date: 1990-05-18 Release date: 1991-07-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation. Biochemistry, 30, 1991
4S0Q	The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and carboplatin Descriptor: Ribonuclease pancreatic, carboplatin Authors: Merlino, A. Deposit date: 2015-01-04 Release date: 2015-11-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts. J.Inorg.Biochem., 153, 2015
7JUH	C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Man-alpha1-6Man Descriptor: CALCIUM ION, Macrophage mannose receptor 1, alpha-D-mannopyranose Authors: Weis, W.I, Feinberg, H. Deposit date: 2020-08-19 Release date: 2021-02-03 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. J.Biol.Chem., 296, 2021
5FRB	Crystal structure of sterol 14-alpha demethylase (CYP51B) from a pathogenic filamentous fungus Aspergillus fumigatus in complex with a tetrazole-based inhibitor VT-1598 Descriptor: (R)-4-((4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)ethynyl)phenoxy)methyl)benzonitrile, PROTOPORPHYRIN IX CONTAINING FE, STEROL 14-ALPHA DEMETHYLASE, ... Authors: Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I. Deposit date: 2015-12-16 Release date: 2017-04-26 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14 alpha-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity. Antimicrob. Agents Chemother., 61, 2017
8BZJ	Human MST3 (STK24) kinase in complex with inhibitor MRLW5 Descriptor: 1,2-ETHANEDIOL, 8-(4-azanylbutyl)-6-[2-chloranyl-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, Serine/threonine-protein kinase 24 Authors: Balourdas, D.I, Rak, M, Tesch, R, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) Deposit date: 2022-12-14 Release date: 2023-01-18 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Development of Selective Pyrido[2,3- d ]pyrimidin-7(8 H )-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. J.Med.Chem., 67, 2024
7PVU	Crystal structure of p38alpha C162S in complex with CAS2094511-69-8, P 1 21 1 Descriptor: Mitogen-activated protein kinase 14, N-(2-cyclobutyl-1H-1,3-benzodiazol-5-yl)-2-fluorobenzene-1-sulfonamide Authors: Baginski, B, Pous, J, Gonzalez, L, Macias, M.J, Nebreda, A.R. Deposit date: 2021-10-05 Release date: 2023-05-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.154 Å) Cite: Characterization of p38 alpha autophosphorylation inhibitors that target the non-canonical activation pathway. Nat Commun, 14, 2023
5FSA	Crystal structure of sterol 14-alpha demethylase (CYP51) from a pathogenic yeast Candida albicans in complex with the antifungal drug posaconazole Descriptor: CYP51 VARIANT1, POSACONAZOLE, PROTOPORPHYRIN IX CONTAINING FE Authors: Hargrove, T.Y, Wawrzak, Z, Friggeri, L, Lepesheva, G.I. Deposit date: 2016-01-02 Release date: 2017-03-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.86 Å) Cite: Structural analyses of Candida albicans sterol 14 alpha-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. J. Biol. Chem., 292, 2017
8BZI	Human MST3 (STK24) kinase in complex with inhibitor MR39 Descriptor: 1,2-ETHANEDIOL, 8-(4-azanylbutyl)-6-[2,5-bis(fluoranyl)-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, Serine/threonine-protein kinase 24 Authors: Balourdas, D.I, Rak, M, Tesch, R, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) Deposit date: 2022-12-14 Release date: 2023-01-18 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily. Eur.J.Med.Chem., 254, 2023
4TKB	The 0.86 angstrom X-ray structure of the human heart fatty acid-binding protein complexed with lauric acid Descriptor: Fatty acid-binding protein, heart, HEXAETHYLENE GLYCOL, ... Authors: Sugiyama, S, Matsuoka, S, Mizohata, E, Matsuoka, D, Ishida, H, Hirose, M, Kakinouchi, K, Hara, T, Murakami, S, Inoue, T, Murata, M. Deposit date: 2014-05-26 Release date: 2015-01-28 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (0.86 Å) Cite: Water-mediated recognition of simple alkyl chains by heart-type Fatty-Acid-binding protein Angew.Chem.Int.Ed.Engl., 54, 2015
6WAX	C-terminal SH2 domain of p120RasGAP Descriptor: 1,2-ETHANEDIOL, Ras GTPase-activating protein 1, SULFATE ION Authors: Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J. Deposit date: 2020-03-26 Release date: 2020-06-17 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain. J.Biol.Chem., 295, 2020
8C7Z	Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2308 Descriptor: 1,2-ETHANEDIOL, 9-piperazin-1-yl-4-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1]benzoxepino[5,4-c]pyridine, AMMONIUM ION, ... Authors: Cros, J, Williams, E.P, Sweeney, M.N, Smil, D, Gonzalez-Alvarez, H, Al-awar, R, Bullock, A.N. Deposit date: 2023-01-18 Release date: 2023-02-01 Last modified: 2024-08-14 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Discovery of Conformationally Constrained ALK2 Inhibitors. J.Med.Chem., 67, 2024
8CCN	Filamentous actin II from Plasmodium falciparum Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin-2, MAGNESIUM ION Authors: Kursula, I, Lopez, A.J. Deposit date: 2023-01-27 Release date: 2023-02-22 Last modified: 2023-08-23 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structure and function of Plasmodium actin II in the parasite mosquito stages. Plos Pathog., 19, 2023
7PTI	STRUCTURAL EFFECTS INDUCED BY REMOVAL OF A DISULFIDE BRIDGE. THE X-RAY STRUCTURE OF THE C30A(SLASH)C51A MUTANT OF BASIC PANCREATIC TRYPSIN INHIBITOR AT 1.6 ANGSTROMS Descriptor: BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION Authors: Eigenbrot, C, Randal, M, Kossiakoff, A.A. Deposit date: 1990-03-08 Release date: 1991-04-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural effects induced by removal of a disulfide-bridge: the X-ray structure of the C30A/C51A mutant of basic pancreatic trypsin inhibitor at 1.6 A. Protein Eng., 3, 1990
4TN1	Translation initiation factor eIF5B (517-858) mutant D533R from C. thermophilum, bound to GTPgammaS Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, eIF5B Authors: Kuhle, B, Ficner, R. Deposit date: 2014-06-02 Release date: 2014-09-24 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.75 Å) Cite: A monovalent cation acts as structural and catalytic cofactor in translational GTPases. Embo J., 33, 2014
8C7W	Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2304 Descriptor: 1,2-ETHANEDIOL, 6-methyl-9-piperazin-1-yl-4-(3,4,5-trimethoxyphenyl)-5,7-dihydropyrido[4,3-d][2]benzazepine, Activin receptor type I, ... Authors: Cros, J, Williams, E.P, Sweeney, M.N, Smil, D, Gonzalez-Alvarez, H, Al-awar, R, Bullock, A.N. Deposit date: 2023-01-17 Release date: 2023-02-08 Last modified: 2024-08-14 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Discovery of Conformationally Constrained ALK2 Inhibitors. J.Med.Chem., 67, 2024
7QNP	Designed Armadillo repeat protein N(A4)M4C(AII) co-crystallized with hen egg white lysozyme Descriptor: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, Designed Armadillo Repeat Protein N(A4)M4C(AII), ... Authors: Michel, E, Mittl, P.R.E, Plueckthun, A. Deposit date: 2021-12-21 Release date: 2022-06-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.586 Å) Cite: Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design. Biochemistry, 62, 2023
4TU9	STRUCTURE OF U2AF65 VARIANT WITH BRU5G6 DNA Descriptor: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*DG*U)-3'), GLYCEROL, ... Authors: Jenkins, J.L, McLaughlin, K.J, Agrawal, A.A, Kielkopf, C.L. Deposit date: 2014-06-24 Release date: 2014-11-26 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.992 Å) Cite: Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA. Proc.Natl.Acad.Sci.USA, 111, 2014
4RLD	Crystal structure of kkf mutant of bla G 2 protein Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aspartic protease Bla g 2, ZINC ION Authors: Li, M, Gustchina, A, Pomes, A, Wlodawer, A. Deposit date: 2014-10-16 Release date: 2015-10-21 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.9 Å) Cite: to be determined To be Published
7Q5W	The tandem SH2 domains of SYK with a bound TYROBP diphospho-ITAM peptide Descriptor: 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, DI(HYDROXYETHYL)ETHER, ... Authors: Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E. Deposit date: 2021-11-04 Release date: 2021-11-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The tandem SH2 domains of SYK To Be Published
7Q63	The tandem SH2 domains of SYK Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E. Deposit date: 2021-11-05 Release date: 2021-11-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The tandem SH2 domains of SYK To Be Published
7JLY	Crystal Structure of RNA Binding Protein PG1 Descriptor: ACETATE ION, CALCIUM ION, RNA-binding protein Authors: Musayev, F.N, Scarsdale, J.N, Belvin, B.R, Lewis, J.P. Deposit date: 2020-07-30 Release date: 2021-07-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.73 Å) Cite: High Resolution Structure of RNA Binding Protein PG1 To be published
4TRY	Structure of BACE1 complex with a HEA-type inhibitor Descriptor: Beta-secretase 1, GLU-ILE-TIH-THC-NVA Authors: Akaji, K, Teruya, K, Akiyama, T, Sanjho, A, Yamashita, E, Nakagawa, A. Deposit date: 2014-06-18 Release date: 2015-07-29 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Structure of BACE1 complex with an anti-HMC-type inhibitor to be published

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