5FSA

Crystal structure of sterol 14-alpha demethylase (CYP51) from a pathogenic yeast Candida albicans in complex with the antifungal drug posaconazole

Summary for 5FSA

Entry DOI	10.2210/pdb5fsa/pdb
Related	5TZI
Descriptor	CYP51 VARIANT1, PROTOPORPHYRIN IX CONTAINING FE, POSACONAZOLE, ... (4 entities in total)
Functional Keywords	cytochrome p450, heme, oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane, oxidoreductase-oxidoreductase inhibitor complex
Biological source	CANDIDA ALBICANS
Total number of polymer chains	2
Total formula weight	115504.90
Authors	Hargrove, T.Y.,Wawrzak, Z.,Friggeri, L.,Lepesheva, G.I. (deposition date: 2016-01-02, release date: 2017-03-15, Last modification date: 2024-01-10)
Primary citation	Hargrove, T.Y.,Friggeri, L.,Wawrzak, Z.,Qi, A.,Hoekstra, W.J.,Schotzinger, R.J.,York, J.D.,Guengerich, F.P.,Lepesheva, G.I. Structural analyses of Candida albicans sterol 14 alpha-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. J. Biol. Chem., 292:6728-6743, 2017 Cited by PubMed: 28258218 DOI: 10.1074/jbc.M117.778308 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.86 Å)

Structure validation