5FSA

Crystal structure of sterol 14-alpha demethylase (CYP51) from a pathogenic yeast Candida albicans in complex with the antifungal drug posaconazole

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001766	biological_process	membrane raft polarization
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006696	biological_process	ergosterol biosynthetic process
A	0007032	biological_process	endosome organization
A	0008202	biological_process	steroid metabolic process
A	0008398	molecular_function	sterol 14-demethylase activity
A	0016020	cellular_component	membrane
A	0016126	biological_process	sterol biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0032541	cellular_component	cortical endoplasmic reticulum
A	0036187	biological_process	cell growth mode switching, budding to filamentous
A	0046872	molecular_function	metal ion binding
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0097038	cellular_component	perinuclear endoplasmic reticulum
B	0001766	biological_process	membrane raft polarization
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006694	biological_process	steroid biosynthetic process
B	0006696	biological_process	ergosterol biosynthetic process
B	0007032	biological_process	endosome organization
B	0008202	biological_process	steroid metabolic process
B	0008398	molecular_function	sterol 14-demethylase activity
B	0016020	cellular_component	membrane
B	0016126	biological_process	sterol biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0020037	molecular_function	heme binding
B	0032541	cellular_component	cortical endoplasmic reticulum
B	0036187	biological_process	cell growth mode switching, budding to filamentous
B	0046872	molecular_function	metal ion binding
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	0097038	cellular_component	perinuclear endoplasmic reticulum

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM A 580

Chain	Residue
A	TYR118
A	PRO462
A	HIS468
A	ARG469
A	CYS470
A	ILE471
A	X2N590
A	HOH2052
A	TYR132
A	LEU139
A	LYS143
A	GLY308
A	THR311
A	PRO375
A	ILE379
A	ARG381

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE X2N A 590

Chain	Residue
A	ALA61
A	TYR118
A	LEU121
A	PHE126
A	ILE131
A	PHE228
A	PRO230
A	PHE233
A	GLY307
A	LEU376
A	HIS377
A	SER506
A	SER507
A	MET508
A	HEM580
A	HOH2045

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEM B 580

Chain	Residue
B	TYR118
B	TYR132
B	LYS143
B	GLY308
B	THR311
B	THR315
B	PRO375
B	ILE379
B	ARG381
B	PRO462
B	PHE463
B	HIS468
B	CYS470
B	ILE471
B	GLY472
B	PHE475
B	X2N590
B	HOH2057

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE X2N B 590

Chain	Residue
B	ALA61
B	TYR64
B	GLY65
B	GLN66
B	LEU121
B	PHE126
B	PHE228
B	PRO230
B	GLY303
B	GLY307
B	LEU376
B	HIS377
B	SER506
B	SER507
B	MET508
B	HEM580

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGgGRHRCIG

Chain	Residue	Details
A	PHE463-GLY472

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"5TZ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"5V5Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"5FSA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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