5FSA
Crystal structure of sterol 14-alpha demethylase (CYP51) from a pathogenic yeast Candida albicans in complex with the antifungal drug posaconazole
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | CYP51 VARIANT1 | polymer | 490 | 56435.2 | 2 | UniProt (Q9P4W0) Pfam (PF00067) UniProt (by SIFTS) (P10613) | CANDIDA ALBICANS | STEROL 14ALPHA-DEMETHYLASE |
| 2 | C, E (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, F (A, B) | POSACONAZOLE | non-polymer | 700.8 | 2 | Chemie (X2N) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 127 | Chemie (HOH) |
Sequence modifications
A, B: 49 - 528 (UniProt: Q9P4W0)
| PDB | External Database | Details |
|---|---|---|
| Met 43 | - | expression tag |
| Ala 44 | - | expression tag |
| Lys 45 | - | expression tag |
| Lys 46 | - | expression tag |
| Thr 47 | - | expression tag |
| Pro 48 | - | expression tag |
| His 529 | - | expression tag |
| His 530 | - | expression tag |
| His 531 | - | expression tag |
| His 532 | - | expression tag |
| Leu 263 | Ser 263 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 112870.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2634.5 | |
| All* | Total formula weight | 115504.9 |
