5FPN
Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 3,5-dimethyl-1H-pyrazole-4-carboxylic acid (AT9084) in an alternate binding site.
Summary for 5FPN
| Entry DOI | 10.2210/pdb5fpn/pdb |
| Related | 5FP5 5FP6 5FPD 5FPE 5FPM 5FPO 5FPR 5FPS 5FPT 5FPY |
| Descriptor | HEAT SHOCK-RELATED 70 KDA PROTEIN 2, 3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID (3 entities in total) |
| Functional Keywords | signaling protein, heat shock, chaperone, hsp70, hspa2, protein-ligand complex, fragment screening, alternate binding site, at9084. |
| Biological source | HOMO SAPIENS (HUMAN) |
| Total number of polymer chains | 2 |
| Total formula weight | 141032.53 |
| Authors | Jhoti, H.,Ludlow, R.F.,Patel, S.,Saini, H.K.,Tickle, I.J.,Verdonk, M. (deposition date: 2015-12-02, release date: 2015-12-23, Last modification date: 2024-01-10) |
| Primary citation | Ludlow, R.F.,Verdonk, M.L.,Saini, H.K.,Tickle, I.J.,Jhoti, H. Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112:15910-, 2015 Cited by PubMed: 26655740DOI: 10.1073/PNAS.1518946112 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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