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5FPN

Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 3,5-dimethyl-1H-pyrazole-4-carboxylic acid (AT9084) in an alternate binding site.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000795cellular_componentsynaptonemal complex
A0001673cellular_componentmale germ cell nucleus
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006986biological_processresponse to unfolded protein
A0007140biological_processmale meiotic nuclear division
A0007141biological_processmale meiosis I
A0007283biological_processspermatogenesis
A0007286biological_processspermatid development
A0009408biological_processresponse to heat
A0009409biological_processresponse to cold
A0009986cellular_componentcell surface
A0010971biological_processpositive regulation of G2/M transition of mitotic cell cycle
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0019899molecular_functionenzyme binding
A0030154biological_processcell differentiation
A0031072molecular_functionheat shock protein binding
A0032781biological_processpositive regulation of ATP-dependent activity
A0036128cellular_componentCatSper complex
A0042026biological_processprotein refolding
A0044183molecular_functionprotein folding chaperone
A0048156molecular_functiontau protein binding
A0051082molecular_functionunfolded protein binding
A0051085biological_processchaperone cofactor-dependent protein refolding
A0051087molecular_functionprotein-folding chaperone binding
A0051861molecular_functionglycolipid binding
A0070062cellular_componentextracellular exosome
A0070194biological_processsynaptonemal complex disassembly
A0072562cellular_componentblood microparticle
A0072687cellular_componentmeiotic spindle
A0090084biological_processnegative regulation of inclusion body assembly
A0097718molecular_functiondisordered domain specific binding
A0140662molecular_functionATP-dependent protein folding chaperone
A1901896biological_processpositive regulation of ATPase-coupled calcium transmembrane transporter activity
B0000795cellular_componentsynaptonemal complex
B0001673cellular_componentmale germ cell nucleus
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0006986biological_processresponse to unfolded protein
B0007140biological_processmale meiotic nuclear division
B0007141biological_processmale meiosis I
B0007283biological_processspermatogenesis
B0007286biological_processspermatid development
B0009408biological_processresponse to heat
B0009409biological_processresponse to cold
B0009986cellular_componentcell surface
B0010971biological_processpositive regulation of G2/M transition of mitotic cell cycle
B0016020cellular_componentmembrane
B0016887molecular_functionATP hydrolysis activity
B0019899molecular_functionenzyme binding
B0030154biological_processcell differentiation
B0031072molecular_functionheat shock protein binding
B0032781biological_processpositive regulation of ATP-dependent activity
B0036128cellular_componentCatSper complex
B0042026biological_processprotein refolding
B0044183molecular_functionprotein folding chaperone
B0048156molecular_functiontau protein binding
B0051082molecular_functionunfolded protein binding
B0051085biological_processchaperone cofactor-dependent protein refolding
B0051087molecular_functionprotein-folding chaperone binding
B0051861molecular_functionglycolipid binding
B0070062cellular_componentextracellular exosome
B0070194biological_processsynaptonemal complex disassembly
B0072562cellular_componentblood microparticle
B0072687cellular_componentmeiotic spindle
B0090084biological_processnegative regulation of inclusion body assembly
B0097718molecular_functiondisordered domain specific binding
B0140662molecular_functionATP-dependent protein folding chaperone
B1901896biological_processpositive regulation of ATPase-coupled calcium transmembrane transporter activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE KYD A 1385
ChainResidue
AARG49
ASER121
AMET122
ATHR125
AILE164

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE KYD A 1386
ChainResidue
AHOH2407
AARG274
ASER277
AGLY341
AARG344

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE KYD B 1385
ChainResidue
BARG274
BSER277
BGLY341
BARG344
BILE345

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE KYD B 1386
ChainResidue
BARG49
BSER121
BMET122
BTHR125
BILE164
BHOH2391

Functional Information from PROSITE/UniProt
site_idPS00297
Number of Residues8
DetailsHSP70_1 Heat shock hsp70 proteins family signature 1. IDLGTTyS
ChainResidueDetails
AILE9-SER16

site_idPS00329
Number of Residues14
DetailsHSP70_2 Heat shock hsp70 proteins family signature 2. IFDLGGGTfdvSIL
ChainResidueDetails
AILE199-LEU212

site_idPS01036
Number of Residues15
DetailsHSP70_3 Heat shock hsp70 proteins family signature 3. IvLvGGsTRIPkIqK
ChainResidueDetails
AILE336-LYS350

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING:
ChainResidueDetails
AGLY12
BGLY341
ALYS71
AGLY204
AGLU270
AGLY341
BGLY12
BLYS71
BGLY204
BGLU270

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P14659
ChainResidueDetails
ASER402
BSER402

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P14659
ChainResidueDetails
ATHR407
ATHR413
BTHR407
BTHR413

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6,N6,N6-trimethyllysine; by METTL21A; in vitro => ECO:0000269|PubMed:23921388
ChainResidueDetails
ALYS563
BLYS563

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PDB entries from 2024-09-11

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