4TU9

STRUCTURE OF U2AF65 VARIANT WITH BRU5G6 DNA

Summary for 4TU9

Related4TU7 4TU8
DescriptorSplicing factor U2AF 65 kDa subunit, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*DG*U)-3'), 1,4-DIETHYLENE DIOXIDE, ... (7 entities in total)
Functional Keywordsrna splicing factor, rna recognition motif, rna binding protein, rna binding protein-dna complex, rna binding protein/dna
Biological sourceHomo sapiens (Human)
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Total number of polymer chains4
Total molecular weight44422.95
Authors
Jenkins, J.L.,McLaughlin, K.J.,Agrawal, A.A.,Kielkopf, C.L. (deposition date: 2014-06-24, release date: 2014-11-26, Last modification date: 2019-12-25)
Primary citation
Agrawal, A.A.,McLaughlin, K.J.,Jenkins, J.L.,Kielkopf, C.L.
Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.
Proc.Natl.Acad.Sci.USA, 111:17420-17425, 2014
PubMed: 25422459 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1412743111
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.992 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23540 2.5% 4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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169963
PDB entries from 2020-10-14