4TU8

STRUCTURE OF U2AF65 VARIANT WITH BRU5A6 DNA

Summary for 4TU8

• Entry DOI: 10.2210/pdb4tu8/pdb
• Related: 4TU7 4TU9
• Descriptor: Splicing factor U2AF 65 kDa subunit, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*DA*U)-3'), 1,4-DIETHYLENE DIOXIDE, ... (8 entities in total)
• Functional Keywords: rna splicing factor, rna recognition motif, rna binding protein, rna binding protein-dna complex, rna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 44745.49

Authors

MCLAUGHLIN, K.J.,JENKINS, J.L.,Agrawal, A.A.,KIELKOPF, C.L. (deposition date: 2014-06-24, release date: 2014-11-26, Last modification date: 2023-12-27)

• Primary citation: Agrawal, A.A.,McLaughlin, K.J.,Jenkins, J.L.,Kielkopf, C.L.; Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.; Proc.Natl.Acad.Sci.USA, 111:17420-17425, 2014; PubMed: 25422459; DOI: 10.1073/pnas.1412743111

Experimental method

X-RAY DIFFRACTION (1.918 Å)