4TU8
STRUCTURE OF U2AF65 VARIANT WITH BRU5A6 DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Splicing factor U2AF 65 kDa subunit | polymer | 174 | 19075.8 | 2 | UniProt (P26368) Pfam (PF00076) | Homo sapiens (Human) | U2 auxiliary factor 65 kDa subunit,hU2AF65,U2 snRNP auxiliary factor large subunit |
| 2 | C, D (P, E) | DNA (5'-D(*UP*UP*UP*UP*(BRU)P*DA*U)-3') | polymer | 7 | 2088.1 | 2 | Homo sapiens | ||
| 3 | E, F, O, P, Q... (A, B) | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 7 | Chemie (DIO) | |||
| 4 | G (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | H, I, J, K, L... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 6 | M, N, Y (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 7 | T (B) | N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE | non-polymer | 862.1 | 1 | Chemie (CPQ) | |||
| 8 | AA, BA, CA, Z (B, P, E, A) | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence modifications
A, B: 148 - 336 (UniProt: P26368)
| PDB | External Database | Details |
|---|---|---|
| Gly 143 | - | expression tag |
| Pro 144 | - | expression tag |
| Leu 145 | - | expression tag |
| Gly 146 | - | expression tag |
| Ser 147 | - | expression tag |
| - | Met 238 | deletion |
| - | Ser 239 | deletion |
| - | Glu 240 | deletion |
| - | Asn 241 | deletion |
| - | Pro 242 | deletion |
| - | Ser 243 | deletion |
| - | Val 244 | deletion |
| - | Tyr 245 | deletion |
| - | Val 246 | deletion |
| - | Pro 247 | deletion |
| - | Gly 248 | deletion |
| - | Val 249 | deletion |
| - | Val 250 | deletion |
| - | Ser 251 | deletion |
| - | Thr 252 | deletion |
| - | Val 253 | deletion |
| - | Val 254 | deletion |
| - | Pro 255 | deletion |
| - | Asp 256 | deletion |
| - | Ser 257 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 42327.8 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 2417.7 | |
| All* | Total formula weight | 44745.5 |
